| Title: |
Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers |
| Authors: |
Zhang, L; Lan, Q; Ji, Z; Li, G; Shen, M; Vermeulen, R; Guo, W; Hubbard, AE; McHale, CM; Rappaport, SM; Hayes, RB; Linet, MS; Yin, S; Smith, MT; Rothman, N |
| Source: |
Leukemia, vol 26, iss 12 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2012 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3201 Cardiovascular Medicine and Haematology (for-2020); Pediatric (rcdc); Rare Diseases (rcdc); Regenerative Medicine (rcdc); Stem Cell Research - Nonembryonic - Non-Human (rcdc); Hematology (rcdc); Stem Cell Research (rcdc); Cancer (rcdc); Stem Cell Research - Nonembryonic - Human (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Adult (mesh); Aneuploidy (mesh); Benzene (mesh); Case-Control Studies (mesh); Chromosome Deletion (mesh); Chromosomes; Human; Pair 7 (mesh); Pair 8 (mesh); Colony-Forming Units Assay (mesh); Cross-Sectional Studies (mesh); Female (mesh); Follow-Up Studies (mesh); Humans (mesh); In Situ Hybridization; Fluorescence (mesh); Leukemia; Myeloid; Acute (mesh) |
| Time: |
2494 - 2498 |
| Description: |
Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit–granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3wv3b950; https://escholarship.org/uc/item/3wv3b950; https://escholarship.org/content/qt3wv3b950/qt3wv3b950.pdf |
| DOI: |
10.1038/leu.2012.143 |
| Availability: |
https://escholarship.org/uc/item/3wv3b950; https://escholarship.org/content/qt3wv3b950/qt3wv3b950.pdf; https://doi.org/10.1038/leu.2012.143 |
| Rights: |
public |
| Accession Number: |
edsbas.5FCE3DF |
| Database: |
BASE |