| Title: |
IKKβ Is Required for Peripheral B Cell Survival and Proliferation |
| Authors: |
Li, Zhi-Wei; Omori, Sidne A; Labuda, Tord; Karin, Michael; Rickert, Robert C |
| Source: |
The Journal of Immunology ; volume 170, issue 9, page 4630-4637 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2003 |
| Description: |
NF-κB activity in mammalian cells is regulated through the IκB kinase (IKK) complex, consisting of two catalytic subunits (IKKα and IKKβ) and a regulatory subunit (IKKγ). Targeted deletion of Ikkβ results in early embryonic lethality, thus complicating the examination of IKKβ function in adult tissues. Here we describe the role of IKKβ in B lymphocytes made possible by generation of a mouse strain that expresses a conditional Ikkβ allele. We find that the loss of IKKβ results in a dramatic reduction in all peripheral B cell subsets due to associated defects in cell survival. IKKβ-deficient B cells are also impaired in mitogenic responses to LPS, anti-CD40, and anti-IgM, indicating a general defect in the ability to activate the canonical NF-κB signaling pathway. These findings are consistent with a failure to mount effective Ab responses to T cell-dependent and independent Ags. Thus, IKKβ provides a requisite role in B cell activation and maintenance and thus is a key determinant of humoral immunity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.170.9.4630 |
| Availability: |
https://doi.org/10.4049/jimmunol.170.9.4630; https://academic.oup.com/jimmunol/article-pdf/170/9/4630/62565681/4630.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.5FF135D2 |
| Database: |
BASE |