| Title: |
Human leukocyte antigen-G in hepatocellular carcinoma driven by chronic viral hepatitis or steatotic liver disease |
| Authors: |
Mocci S.; Perra A.; Littera R.; Pes F.; Melis M.; Sanna C.; Mascia A.; Murgia M.; Mereu C.; Lorrai M.; Dus-Ilnicka I.; Zedda G.; Lai S.; Giuressi E.; Guarino F.; Serra G.; Miglianti M.; Stradoni R.; Vacca M.; Zolfino T.; Chessa L.; Giglio S. |
| Contributors: |
Mocci, S.; Perra, A.; Littera, R.; Pes, F.; Melis, M.; Sanna, C.; Mascia, A.; Murgia, M.; Mereu, C.; Lorrai, M.; Dus-Ilnicka, I.; Zedda, G.; Lai, S.; Giuressi, E.; Guarino, F.; Serra, G.; Miglianti, M.; Stradoni, R.; Vacca, M.; Zolfino, T.; Chessa, L.; Giglio, S. |
| Publisher Information: |
Springer Nature London |
| Publication Year: |
2025 |
| Subject Terms: |
CC; HBV; HCV; HLA-G; sHLA-G; SLD |
| Description: |
Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the third leading cause of cancer-related mortality, primarily driven by viral infections (HCV, HBV) and steatotic liver diseases (SLD). Despite advances in treatment, early detection and accurate prognosis remain challenging. The Human leukocyte antigen G (HLA-G) molecule is dysregulated in various conditions, including cancers and viral infections. This study aimed to investigate HLA-G’s role in viral-related and SLD-driven HCC. We analyzed a cohort of 116 HCC patients and 140 healthy controls to assess HLA-G genetic variants and soluble levels. Results showed significantly higher levels of soluble HLA-G in HCC patients compared to controls (Pc = 0.003). Moreover, overall survival (OS) was significantly lower in patients with the extended HLA-G*01:01:01/UTR-1 haplotype (Log-rank test, p = 0.002), a trend consistent in both HCV and/or HBV-related HCC (p = 0.025) and SLD-related HCC (p = 0.018). Elevated sHLA-G levels were associated with shorter OS across both subgroups (p = 0.034 (HBV/HCV) and p = 0.010 (SLD), respectively). The findings suggest that elevated levels of soluble HLA-G and specific genetic variants are associated with poor prognosis in HCC patients, highlighting the potential of HLA-G as a prognostic biomarker in both viral-related and steatotic liver disease-related HCC. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40246934; info:eu-repo/semantics/altIdentifier/wos/WOS:001470272500010; volume:15; issue:1; numberofpages:15; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/20.500.11768/196297 |
| DOI: |
10.1038/s41598-025-97406-4 |
| Availability: |
https://hdl.handle.net/20.500.11768/196297; https://doi.org/10.1038/s41598-025-97406-4; https://www.nature.com/articles/s41598-025-97406-4 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.5FF3DB18 |
| Database: |
BASE |