| Title: |
CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas |
| Authors: |
Virgili Manrique, Anna Cristina; Salazar, Juliana; Gallardo, Alberto; López Pousa, Antonio; Terés Lleida, Raúl; Bagué Rosell, Sílvia; Orellana Fernández, Ruth; Fumagalli, Caterina; Mangues, Ramon; Alba Castellón, Lorena; Unzueta Elorza, Ugutz; Casanova Rigat, Isolda; Sebio, Ana; Universitat Autònoma de Barcelona |
| Publication Year: |
2024 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
CXCR4; Prognostic factor; Soft tissue sarcomas; Synovial sarcomas; Undifferentiated pleomorphic sarcomas |
| Description: |
Poor long-term survival in localized high-risk soft tissue sarcomas (STSs) of the extremities and trunk highlights the need to identify new prognostic factors. CXCR4 is a chemokine receptor involved in tumor progression, angiogenesis, and metastasis. The aim of this study was to evaluate the association between CXCR4 expression in tumor tissue and survival in STSs patients treated with neoadjuvant therapy. CXCR4 expression was retrospectively determined by immunohistochemical analysis in serial specimens including initial biopsies, tumors post-neoadjuvant treatment, and tumors after relapse. We found that a positive cytoplasmatic expression of CXCR4 in tumors after neoadjuvant treatment was a predictor of poor recurrence-free survival (RFS) (p = 0.003) and overall survival (p = 0.019) in synovial sarcomas. We also found that positive nuclear CXCR4 expression in the initial biopsies was associated with poor RFS (p = 0.022) in undifferentiated pleomorphic sarcomas. In conclusion, our study adds to the evidence that CXCR4 expression in tumor tissue is a promising prognostic factor for STSs. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
14111195; 20754418 |
| Relation: |
Diagnostics; Vol. 14 Núm. 11 (june 2024), p. 1195; https://ddd.uab.cat/record/294261; urn:10.3390/diagnostics14111195; urn:oai:ddd.uab.cat:294261; urn:scopus_id:85195925678; urn:articleid:20754418v14n11a1195; urn:pmid:38893721; urn:pmcid:PMC11172351; urn:oai:pubmedcentral.nih.gov:11172351 |
| Availability: |
https://ddd.uab.cat/record/294261 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.601F6FA1 |
| Database: |
BASE |