| Title: |
Mitochondrial Dynamics in Brain Cells During Normal and Pathological Aging |
| Authors: |
Vladimir S. Sukhorukov; Tatiana I. Baranich; Anna V. Egorova; Anastasia V. Akateva; Kseniia M. Okulova; Maria S. Ryabova; Krisitina A. Skvortsova; Oscar V. Dmitriev; Natalia M. Mudzhiri; Dmitry N. Voronkov; Sergey N. Illarioshkin |
| Source: |
International Journal of Molecular Sciences ; Volume 25 ; Issue 23 ; Pages: 12855 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2024 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
mitochondrial dynamics; neurodegeneration; mitophagy; neuroprotection |
| Subject Geographic: |
agris |
| Description: |
Mitochondrial dynamics significantly play a major role in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. The dysregulation of mitochondrial biogenesis and function, characterized by impaired fission and fusion processes mediated by a number of proteins, in particular, Drp1, Mfn1, Mfn2, Opa1, and PGC-1α, contributes to neuronal vulnerability and degeneration. Insufficient mitophagy and disrupted mitochondrial transport exacerbate oxidative stress and neurotoxicity. Emerging therapeutic strategies that target mitochondrial dynamics, including various pharmacological agents, demonstrate potential for restoring mitochondrial balance and enhancing neuroprotection. This growing body of research underscores the importance of mitochondrial health in developing effective interventions for neurodegenerative conditions. This review highlights well-established links between the disruption of mitochondrial dynamics and the development of neurodegenerative processes. We also discuss different therapeutic strategies that target mitochondrial function in neurons that have been proposed as perspective neuroprotective treatments. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms252312855 |
| DOI: |
10.3390/ijms252312855 |
| Availability: |
https://doi.org/10.3390/ijms252312855 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.60220831 |
| Database: |
BASE |