| Title: |
Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea - The ESADA cohort |
| Authors: |
Zou D.; Grote L.; Basoglu O. K.; Verbraecken J.; Schiza S.; Sliwinski P.; Steiropoulos P.; Lombardi C.; Hein H.; Pepin J. -L.; Parati G.; McNicholas W. T.; Hedner J.; Petiet E.; Trakada G.; Fietze I.; Penzel T.; Ludka O.; Bouloukaki I.; Ryan S.; Riha R. L.; Kvamme J. A.; Pevernagie D.; Bailly S.; Pepin J. L.; Tamisier R.; Tasbakan M. S.; Buskova J.; Joppa P.; Staats R.; Testelmans D.; Gouveris H.; Ludwig K.; Bonsignore M. R.; Fanfulla F.; Drummond M.; van Zeller M.; Randerath W.; Treml M.; Dogas Z.; Pecotic R.; Pataka A.; Mihaicuta S.; Anttalainen U.; Saaresranta T. |
| Contributors: |
Zou D.; Grote L.; Basoglu O.K.; Verbraecken J.; Schiza S.; Sliwinski P.; Steiropoulos P.; Lombardi C.; Hein H.; Pepin J.-L.; Parati G.; McNicholas W.T.; Hedner J.; Petiet E.; Trakada G.; Fietze I.; Penzel T.; Ludka O.; Bouloukaki I.; Ryan S.; Riha R.L.; Kvamme J.A.; Pevernagie D.; Bailly S.; Pepin J.L.; Tamisier R.; Tasbakan M.S.; Buskova J.; Joppa P.; Staats R.; Testelmans D.; Gouveris H.; Ludwig K.; Bonsignore M.R.; Fanfulla F.; Drummond M.; van Zeller M.; Randerath W.; Treml M.; Dogas Z.; Pecotic R.; Pataka A.; Mihaicuta S.; Anttalainen U.; Saaresranta T. |
| Publisher Information: |
Elsevier B.V. |
| Publication Year: |
2023 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
Acid base balance; Biomarker; Blood pressure; Chemosensitivity; Endotype; Precision medicine |
| Description: |
Objective: Blood bicarbonate concentration plays an important role for obstructive sleep apnea (OSA) patients to maintain acid-base balance. We investigated the association between arterial standard bicarbonate ([HCO3-]) and nocturnal hypoxia as well as comorbid hypertension in OSA. Methods: A cross-sectional analysis of 3329 patients in the European Sleep Apnea Database (ESADA) was performed. Arterial blood gas analysis and lung function test were performed in conjunction with polysomnographic sleep studies. The 4% oxygen desaturation index (ODI), mean and minimum oxygen saturation (SpO2), and percentage of time with SpO2 below 90% (T90%) were used to reflect nocturnal hypoxic burden. Arterial hypertension was defined as a physician diagnosis of hypertension with ongoing antihypertensive medication. Hypertensive patients with SBP/DBP below or above 140/90 mmHg were classified as controlled-, uncontrolled hypertension, respectively. Results: The [HCO3-] level was normal in most patients (average 24.0 ± 2.5 mmol/L). ODI, T90% increased whereas mean and minimum SpO2 decreased across [HCO3-] tertiles (ANOVA, p = 0.030, |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36599194; info:eu-repo/semantics/altIdentifier/wos/WOS:000921232600001; volume:102; firstpage:39; lastpage:45; numberofpages:7; journal:SLEEP MEDICINE; https://hdl.handle.net/10447/620241 |
| DOI: |
10.1016/j.sleep.2022.11.041 |
| Availability: |
https://hdl.handle.net/10447/620241; https://doi.org/10.1016/j.sleep.2022.11.041 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.602E5B4B |
| Database: |
BASE |