| Title: |
Direct Antivirals Can Achieve a Cure in All Patients With Chronic Hepatitis C due to Genotype 5: A French Multicentre Study. |
| Authors: |
Nicolas, C.; Domas, Q.; Pol, S.; Bardou-Jacquet, E.; Loustaud-Ratti, V.; Métivier, S.; Asselah, T.; Thabut, D.; Bourlière, M.; Mathurin, Philippe; Foucher, J.; Larrey, D.; Varaut, A.; Alric, L.; Bailly, F.; Muti, L.; Buchard, B.; Abergel, A. |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286 |
| Publication Year: |
2025 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
direct-acting antiviral; genotype 5; hepatitis C virus; real-world; sustained virological response |
| Description: |
Background: Hepatitis C virus genotype 5 (HCV-GT-5) is found mainly in South Africa. In our area in central France, the prevalence of HCV-GT-5 is 14%. Methods and results: Here we evaluated sustained virological response at week 12 post-treatment (SVR12) in 147 HCV-GT-5 patients from 14 French university hospitals (2014-2021) treated with direct-acting antivirals (DAA) in real-life. Patients had mainly received sofosbuvir/ledipasvir ± ribavirin, sofosbuvir/velpatasvir, and glecaprevir/pibrentasvir. Overall SVR12 was 98% (144/147). Two patients experienced relapse: one was successfully retreated with the same DAAs (sofosbuvir/ledipasvir) plus ribavirin, and the other refused further DAA treatment. One patient with virological failure (sofosbuvir/velpatasvir) had received a second treatment (sofosbuvir/velpatasvir/voxilaprevir) and progressed to cure. Conclusions: HCV-GT-5 patients treated with a DAA regimen had a 99% SVR12 in intention-to-treat (including initial therapy and retreatment) and 100% SVR12 per protocol. Sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, and glecaprevir/pibrentasvir show very good efficacy in real-world HCV-GT-5 patients. ; 45;4 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Liver Int; https://hdl.handle.net/20.500.12210/129532 |
| Availability: |
https://hdl.handle.net/20.500.12210/129532 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.6074C689 |
| Database: |
BASE |