| Title: |
Basal metabolic requirements, biomarkers of cardiometabolic health and anthropometric measures of obesity in adults with restricted growth conditions |
| Authors: |
Merrell, LH; Smith, HA; Carroll, H; Yung-Chih, C; Thompson, D; Gonzalez, JT; Atkinson, G |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
RC1200 Sports Medicine |
| Description: |
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements and fasted blood samples were obtained from adults with restricted growth (age 41±14 years, height 1.30±0.10 m, body mass 60.5±18.3 kg, female:male n=24:13, achondroplasia n=26; mean±SD). Basal metabolic rate was 6529 ± 1703 kJ∙d-1 and total mass-normalised energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55±0.73 mmol • L-1), insulin (36.4±19.9 pmol • L-1) and lipids (triacylglycerol 0.84±0.37 mmol • L-1; total cholesterol 4.54±0.85 mmol • L-1; high-density lipoprotein cholesterol 1.41±0.31 mmol • L-1; low-density lipoprotein cholesterol 2.73±0.69 mmol • L-1) were mostly within healthy clinical reference ranges. Sagittal abdominal diameter was positively correlated with plasma glucose and leptin concentrations (r=0.85; 95%CI: 0.61, 0.95; p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1552-4825 |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/26870/1/Basal%20Metabolic%20Requirements%20Biomarkers%20of%20Cardiometabolic%20Health%20and%20Anthropometric%20Measures%20of%20Obesity%20in%20Women%20and%20Men.pdf; Merrell, LH, Smith, HA, Carroll, H, Yung-Chih, C, Thompson, D, Gonzalez, JT and Atkinson, G ORCID logoorcid:0000-0002-5459-9042 (2025) Basal metabolic requirements, biomarkers of cardiometabolic health and anthropometric measures of obesity in adults with restricted growth conditions. American Journal of Medical Genetics, Part A. ISSN 1552-4825 |
| DOI: |
10.1002/ajmg.a.64235 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/26870/; https://researchonline.ljmu.ac.uk/id/eprint/26870/1/Basal%20Metabolic%20Requirements%20Biomarkers%20of%20Cardiometabolic%20Health%20and%20Anthropometric%20Measures%20of%20Obesity%20in%20Women%20and%20Men.pdf; https://doi.org/10.1002/ajmg.a.64235 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.60764BDC |
| Database: |
BASE |