Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial
| Title: | Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial |
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| Authors: | Butler, Christopher C; Hobbs, F D Richard; Gbinigie, Oghenekome A; Rahman, Najib M; Hayward, Gail; Richards, Duncan B; Dorward, Jienchi; Lowe, David M; Standing, Joseph F; Breuer, Judith; Khoo, Saye; Petrou, Stavros; Hood, Kerenza; Nguyen-Van-Tam, Jonathan S; Patel, Mahendra G; Saville, Benjamin R; Marion, Joe; Ogburn, Emma; Allen, Julie; Rutter, Heather; Francis, Nick; Thomas, Nicholas P B; Evans, Philip; Dobson, Melissa; Madden, Tracie-Ann; Holmes, Jane; Harris, Victoria; Png, May Ee; Lown, Mark; van Hecke, Oliver; Detry, Michelle A; Saunders, Christina T; Fitzgerald, Mark; Berry, Nicholas S; Mwandigha, Lazaro; Galal, Ushma; Mort, Sam; Jani, Bhautesh D; Hart, Nigel D; Ahmed, Haroon; Butler, Daniel; McKenna, Micheal; Chalk, Jem; Lavallee, Layla; Hadley, Elizabeth; Cureton, Lucy; Benysek, Magdalena; Andersson, Monique; Coates, Maria; Barrett, Sarah; Bateman, Clare; Davies, Jennifer C; Raymundo-Wood, Ivy; Ustianowski, Andrew; Carson-Stevens, Andrew; Yu, Ly-Mee; Little, Paul; Agyeman, Akosua A; Ahmed, Tanveer; Allcock, Damien; Beltran-Martinez, Adrian; Benedict, Oluseye E; Bird, Nigel; Brennan, Laura; Brown, Julianne; Burns, Gerard; Butler, Mike; Cheng, Zelda; Danson, Ruth; de Kare-Silver, Nigel; Dhasmana, Devesh; Dickson, Jon; Engamba, Serge; Fisher, Stacey; Fox, Robin; Frost, Eve; Gaunt, Richard; Ghosh, Sarit; Gilkar, Ishtiaq; Goodman, Anna; Granier, Steve; Howell, Aleksandra; Hussain, Iqbal; Hutchinson, Simon; Imlach, Marie; Irving, Greg; Jacobsen, Nicholas; Kennard, James; Khan, Umar; Knox, Kyle; Krasucki, Christopher; Law, Tom; Lee, Rem; Lester, Nicola; Lewis, David; Lunn, James; Mackintosh, Claire I.; Mathukia, Mehul; Moore, Patrick; Morton, Seb; Murphy, Daniel; Nally, Rhiannon; Ndukauba, Chinonso; Ogundapo, Olufunto; Okeke, Henry; Patel, Amit; Patel, Kavil; Penfold, Ruth; Poonian, Satveer; Popoola, Olajide; Pora, Alexander; Prasad, Vibhore; Prasad, Rishabh; Razzaq, Omair; Richardson, Scot; Royal, Simon; Safa, Afsana; Sehdev, Satash; Sevenoaks, Tamsin; Shah, Divya; Sheikh, Aadil; Short, Vanessa; Sidhu, Baljinder S; Singh, Ivor; Soni, Yusuf; Thalasselis, Chris; Wilson, Pete; Wingfield, David; Wong, Michael; Woodall, Maximillian N J; Wooding, Nick; Woods, Sharon; Yong, Joanna; Yongblah, Francis; Zafar, Azhar |
| Publisher Information: | Elsevier |
| Publication Year: | 2023 |
| Collection: | Cardiff University: ORCA (Online Research @ Cardiff) |
| Description: | BackgroundThe safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We aimed to establish whether the addition of molnupiravir to usual care reduced hospital admissions and deaths associated with COVID-19 in this population.MethodsPANORAMIC was a UK-based, national, multicentre, open-label, multigroup, prospective, platform adaptive randomised controlled trial. Eligible participants were aged 50 years or older—or aged 18 years or older with relevant comorbidities—and had been unwell with confirmed COVID-19 for 5 days or fewer in the community. Participants were randomly assigned (1:1) to receive 800 mg molnupiravir twice daily for 5 days plus usual care or usual care only. A secure, web-based system (Spinnaker) was used for randomisation, which was stratified by age ( |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/157113/1/1-s2.0-S0140673622025971-main.pdf; Butler, Christopher C https://orca.cardiff.ac.uk/view/cardiffauthors/A0239216.html orcid:0000-0002-0102-3453 orcid:0000-0002-0102-3453, Hobbs, F D Richard, Gbinigie, Oghenekome A, Rahman, Najib M, Hayward, Gail, Richards, Duncan B, Dorward, Jienchi, Lowe, David M, Standing, Joseph F, Breuer, Judith, Khoo, Saye, Petrou, Stavros, Hood, Kerenza https://orca.cardiff.ac.uk/view/cardiffauthors/A075757S.html orcid:0000-0002-5268-8631 orcid:0000-0002-5268-8631, Nguyen-Van-Tam, Jonathan S, Patel, Mahendra G, Saville, Benjamin R, Marion, Joe, Ogburn, Emma, Allen, Julie, Rutter, Heather, Francis, Nick, Thomas, Nicholas P B, Evans, Philip, Dobson, Melissa, Madden, Tracie-Ann https://orca.cardiff.ac.uk/view/cardiffauthors/A001522L.html orcid:0000-0001-7880-7873 orcid:0000-0001-7880-7873, Holmes, Jane, Harris, Victoria, Png, May Ee, Lown, Mark, van Hecke, Oliver, Detry, Michelle A, Saunders, Christina T, Fitzgerald, Mark, Berry, Nicholas S, Mwandigha, Lazaro, Galal, Ushma, Mort, Sam, Jani, Bhautesh D, Hart, Nigel D, Ahmed, Haroon https://orca.cardiff.ac.uk/view/cardiffauthors/A1258479.html orcid:0000-0002-0634-8548 orcid:0000-0002-0634-8548, Butler, Daniel, McKenna, Micheal, Chalk, Jem, Lavallee, Layla, Hadley, Elizabeth, Cureton, Lucy, Benysek, Magdalena, Andersson, Monique, Coates, Maria, Barrett, Sarah, Bateman, Clare, Davies, Jennifer C, Raymundo-Wood, Ivy, Ustianowski, Andrew, Carson-Stevens, Andrew https://orca.cardiff.ac.uk/view/cardiffauthors/A051118V.html orcid:0000-0002-7580-7699 orcid:0000-0002-7580-7699, Yu, Ly-Mee, Little, Paul, Agyeman, Akosua A, Ahmed, Tanveer, Allcock, Damien, Beltran-Martinez, Adrian, Benedict, Oluseye E, Bird, Nigel, Brennan, Laura, Brown, Julianne, Burns, Gerard, Butler, Mike, Cheng, Zelda, Danson, Ruth, de Kare-Silver, Nigel, Dhasmana, Devesh, Dickson, Jon, Engamba, Serge, Fisher, Stacey, Fox, Robin, Frost, Eve, Gaunt, Richard, Ghosh, Sarit, Gilkar, Ishtiaq, Goodman, Anna, Granier, Steve, Howell, Aleksandra, Hussain, Iqbal, Hutchinson, Simon, Imlach, Marie, Irving, Greg, Jacobsen, Nicholas, Kennard, James, Khan, Umar, Knox, Kyle, Krasucki, Christopher, Law, Tom, Lee, Rem, Lester, Nicola, Lewis, David, Lunn, James, Mackintosh, Claire I., Mathukia, Mehul, Moore, Patrick, Morton, Seb, Murphy, Daniel, Nally, Rhiannon, Ndukauba, Chinonso, Ogundapo, Olufunto, Okeke, Henry, Patel, Amit, Patel, Kavil, Penfold, Ruth, Poonian, Satveer, Popoola, Olajide, Pora, Alexander, Prasad, Vibhore, Prasad, Rishabh, Razzaq, Omair, Richardson, Scot, Royal, Simon, Safa, Afsana, Sehdev, Satash, Sevenoaks, Tamsin, Shah, Divya, Sheikh, Aadil, Short, Vanessa, Sidhu, Baljinder S, Singh, Ivor, Soni, Yusuf, Thalasselis, Chris, Wilson, Pete, Wingfield, David, Wong, Michael, Woodall, Maximillian N J, Wooding, Nick, Woods, Sharon, Yong, Joanna, Yongblah, Francis and Zafar, Azhar 2023. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. The Lancet 401 (10373) 10.1016/S0140-6736(22)02597-1 https://doi.org/10.1016/S0140-6736%2822%2902597-1 file https://orca.cardiff.ac.uk/id/eprint/157113/1/1-s2.0-S0140673622025971-main.pdf |
| DOI: | 10.1016/S0140-6736(22)02597-1 |
| Availability: | https://orca.cardiff.ac.uk/id/eprint/157113/; https://doi.org/10.1016/S0140-6736(22)02597-1 |
| Rights: | cc_by_4_0 |
| Accession Number: | edsbas.608B732F |
| Database: | BASE |