| Title: |
SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology |
| Authors: |
Molteni, E; Astley, C; Ma, W; Sudre, CH; Magee, L; Murray, B; Fall, T; Gomez, M; Tsereteli, N; Franks, P; Brownstein, J; Davies, R; Wolf, J; Spector, T; Ourselin, S; Steves, C; Chan, A; Modat, M |
| Source: |
MedRxiv: Cold Spring Harbor, NY, USA. (2020) |
| Publisher Information: |
MedRxiv |
| Publication Year: |
2020 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Objective: To test whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity. To extend previous investigations on hospitalized pregnant women to those who did not require hospitalization. Design: Observational study prospectively collecting longitudinal (smartphone application interface) and cross-sectional (web-based survey) data. Setting:Community-based self-participatory citizen surveillance in the United Kingdom, Sweden and the United States of America. Population: Two female community-based cohorts aged 18-44 years. The discovery cohort was drawn from 1,170,315 UK, Sweden and USA women (79 pregnant tested positive) who self-reported status and symptoms longitudinally via smartphone. The replication cohort included 1,344,966 USA women (134 pregnant tested positive) who provided cross-sectional self-reports. Methods: Pregnant and non-pregnant were compared for frequencies of symptoms and events, including SARS-CoV-2 testing and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Results: Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity. Pregnant were more likely to have received testing than non-pregnant, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with the syndromic severity in pregnant hospitalized women. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among all non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant women who were hospitalized. Conclusions: Symptom characteristics and severity were comparable among pregnant and non-pregnant women, except for gastrointestinal symptoms. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 ... |
| Document Type: |
report |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10108464/1/2020.08.17.20161760v1.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10108464/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10108464/1/2020.08.17.20161760v1.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10108464/ |
| Rights: |
open |
| Accession Number: |
edsbas.60B87A2 |
| Database: |
BASE |