| Title: |
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study |
| Authors: |
Barrett Tracey; Liu Juan; Wang Weifeng; Yu Dongyang; Yoder Alyson; Wu Yuntao; Wheeler David; Schlauch Karen |
| Source: |
Retrovirology, Vol 5, Iss 1, p 95 (2008) |
| Publisher Information: |
BMC |
| Publication Year: |
2008 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Immunologic diseases. Allergy; RC581-607 |
| Description: |
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://www.retrovirology.com/content/5/1/95; https://doaj.org/toc/1742-4690; https://doaj.org/article/f4c7a7c606d546d0a054c1a7f2035ed3 |
| DOI: |
10.1186/1742-4690-5-95 |
| Availability: |
https://doi.org/10.1186/1742-4690-5-95; https://doaj.org/article/f4c7a7c606d546d0a054c1a7f2035ed3 |
| Accession Number: |
edsbas.60C37FF3 |
| Database: |
BASE |