| Title: |
The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients |
| Authors: |
Mizuno, S.; Gras, L.; Baaij, L.G.A.; Koster, L.; D'Souza, A.; Hari, P.N.; Estrada-Merly, N.; Saber, W.; Cowan, A.J.; Iida, M.; Okamoto, S.; Takamatsu, H.; Kawamura, K.; Kodera, Y.; Hamad, N.; Ko, B.-S.; Liam, C.; Ho, K.W.; Goh, A.S.; Keat, T.S.; Elhaddad, A.M.; Bazarbachi, A.; Chaudhry, B.Q.U.N.; Alfar, R.; Bekadja, M.A.; Benakli, M.; Ortiz, C.A.F.; Riva, E.; Verburgh, E.; Galeano, S.; Bass, F.; Mian, H.; McCurdy, A.; Wang, F.R.; Neumann, D.; Koh, M.B.C.; Snowden, J.A.; Schönland, S.; McLornan, D.P.; Hayden, P.J.; Balari, A.M.S.; Greinix, H.T.; Aljurf, M.; Atsuta, Y.; Rondelli, D.; Niederwieser, D.W.; Garderet, L. |
| Publisher Information: |
Ferrata Storti Foundation (Haematologica) |
| Publication Year: |
2026 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Despite the availability of novel agents, autologous hematopoietic cell transplantation (auto-HCT) remains the standard of care in newly diagnosed multiple myeloma (MM) patients. The impact of age on overall survival (OS), progression-free survival (PFS), relapse incidence, non-relapse mortality (NRM), and excess mortality (taking account of general population mortality) was investigated using information on 61,797 MM patients transplanted between 2013 and 2017. The median age at auto-HCT was 60.8 (range: 18.1–83.2) years of whom 2.0% were 18–39 years, 68.9% 40–64 years, 21.8% 65–69 years, 6.5% 70–74 years, and 0.8% ≥75 years of age, respectively. The corresponding OS probabilities at three years were 85.9%, 82.8%, 81.1%, 78.4%, and 74.8%, respectively (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0390-6078 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/230842/8/12198-Article%20Text-88204-2-10-20251211.pdf; Mizuno, S., Gras, L., Baaij, L.G.A. et al. (44 more authors) (2026) The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients. Haematologica, 111 (1). pp. 286-299. ISSN: 0390-6078 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/230842/ |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.61276F02 |
| Database: |
BASE |