| Title: |
The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection:a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium |
| Authors: |
Loef,Bette; Boer,Jolanda M.A.; Beekman,Marian; Campman,Sophie L.; Hoogendijk,Emiel O.; Huider,Floris; Pagen,Demi M.E.; Splinter,Marije J.; van der Velde,Jeroen H.P.M.; Boomsma,Dorret I.; Dagnelie,Pieter C.; van Dongen,Jenny; de Geus,Eco J.C.; Huisman,Martijn; Ikram,M. Arfan; Koster,Annemarie; Licher,Silvan; Mierau,Jochen O.; de Mutsert,Renée; Picavet,H. Susan J.; Rosendaal,Frits R.; Schram,Miranda T.; Slagboom,P. Eline; van der Spoel,Evie; Stronks,Karien; Verschuren, W. M.Monique; van den Berg,Saskia W.; Lifelines Corona Research initiative; Cardiometabolic Health; Circulatory Health; JC onderzoeksprogramma Cardiovascular Health |
| Publication Year: |
2025 |
| Subject Terms: |
Medicine (miscellaneous); Endocrinology; Diabetes and Metabolism; Nutrition and Dietetics; Journal Article |
| Description: |
Background: Obesity may affect an individual’s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection. Methods: We analyzed data from nine prospective population-based cohorts of the Netherlands Cohorts Consortium, with a total of 99,570 participants, following a standardized procedure. Body mass index (BMI) and waist circumference (WC) were assessed two times before the pandemic, with approximately 5 years between measurements. SARS-CoV-2 infection was defined by self-report as a positive PCR or rapid-antigen test or as COVID-19 ascertained by a physician between March 2020 and January 2023. For three cohorts, information on SARS-CoV-2 infection by serology was available. Results were pooled using random-effects meta-analyses and adjusted for age, sex, educational level, and number of SARS-CoV-2 infection measurements. Results: Individuals with overweight (25 ≤ BMI < 30 kg/m2) (odds ratio (OR) = 1.08, 95%-confidence interval (CI) 1.04-1.13) or obesity (BMI ≥ 30 kg/m2) (OR = 1.43, 95%-CI 1.18–1.75) were more likely to report SARS-CoV-2 infection than individuals with a healthy body weight. We observed comparable ORs for abdominal overweight (men: 94 cm≤WC < 102 cm, women: 80 cm≤WC < 88 cm) (OR = 1.09, 95%-CI 1.04–1.14, I2 = 0%) and abdominal obesity (men: WC ≥ 102 cm, women: WC ≥ 88 cm) (OR = 1.24, 95%-CI 0.999–1.55, I2 = 57%). Individuals with obesity long before the pandemic, but with a healthy body weight or overweight just before the pandemic, were not at increased risk. Conclusion: Overweight and obesity were associated with increased risk of SARS-CoV-2 infection with stronger associations for obesity. Individuals with a healthier weight prior to the pandemic but previous obesity did not have an increased risk of SARS-CoV-2, suggesting that weight loss in those with ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0307-0565 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/458835 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/458835 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.61493D09 |
| Database: |
BASE |