| Title: |
Effect of the time of day for vaccination on the immune response to Ebola Virus Disease vaccines: A modeling study from PREVAC randomized trial. |
| Authors: |
Kpetigo, Ange-Marie D; Alexandre, Marie; Camara, Aboubacar; Beavogui, Abdoul; Doumbia, Seydou; Kieh, Mark; Leigh, Bailah; Sow, Samba; Wittkop, Linda; Soutthiphong, Anne-Aygline; Berry, Irina Maljkovic; Fleck, Suzanne; Akoo, Pauline; Hamze, Benjamin; Watson-Jones, Deborah; Kuhn, Jens H; Greenwood, Brian; Richert, Laura; Yazdanpanah, Yazdan; Lévy, Yves; Thiébaut, Rodolphe; Prague, Mélanie; PREVAC Study Team; Lhomme, Edouard |
| Publisher Information: |
Public Library of Science |
| Publication Year: |
2026 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
BACKGROUND: Emerging evidence suggests that the time in the day of vaccination may influence post-vaccination immunogenicity. The main objective of this study was to assess the association between the time of vaccination and the anti-EBOV GP1,2 IgG antibody response at 12 mo following vaccination against Ebola virus disease (EVD). METHODOLOGY/PRINCIPAL FINDINGS: This study utilized data from a randomized, double-blind, placebo-controlled international phase 2b clinical trial (PREVAC) evaluating the immunogenicity of three vaccination strategies against Ebola virus disease (rVSVΔG-ZEBOV-GP one and two doses, and Ad26.ZEBOV/MVA-BN-Filo) in 1,859 healthy Western Africans. In the overall population, we measured a statistically significant association between the time of day of first vaccination and anti-Ebola virus immunoglobulin G levels at 12 mo (p = 0.02). The magnitude of this association was small, participants vaccinated at 1600 h were estimated to have 1-7% lower antibody levels at 12 mo compared to those vaccinated at 1000 h. CONCLUSIONS/SIGNIFICANCE: An effect of the time of first vaccination on the antibody responses was found but remains modest and unlikely to impact the EVD vaccine effectiveness. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov registration: NCT02876328. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1935-2727 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4679683/1/Kpetigo-etal-2026-Effect-of-time-of-day.pdf; Kpetigo, Ange-Marie D; Alexandre, Marie; Camara, Aboubacar; Beavogui, Abdoul; Doumbia, Seydou; Kieh, Mark; Leigh, Bailah; Sow, Samba; Wittkop, Linda; Soutthiphong, Anne-Aygline; +14 more.Berry, Irina Maljkovic; Fleck, Suzanne; Akoo, Pauline; Hamze, Benjamin; Watson-Jones, Deborah ORCID logo; Kuhn, Jens H; Greenwood, Brian ORCID logo; Richert, Laura; Yazdanpanah, Yazdan; Lévy, Yves; Thiébaut, Rodolphe; Prague, Mélanie; PREVAC Study Team; and Lhomme, EdouardORCID logo (2026) Effect of the time of day for vaccination on the immune response to Ebola Virus Disease vaccines: A modeling study from PREVAC randomized trial. PLoS neglected tropical diseases, 20 (1). e0013950-. ISSN 1935-2727 DOI:10.1371/journal.pntd.0013950 |
| DOI: |
10.1371/journal.pntd.0013950 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4679683/; https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0013950; https://doi.org/10.1371/journal.pntd.0013950 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.61985B3E |
| Database: |
BASE |