| Title: |
Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery |
| Authors: |
Kozma C; Horsley J; Hall G; Simpson C; de Tisi J; Miserocchi A; Diehl B; McEvoy AW; Vos SB; Winston GP; Wang Y; Duncan JS; Taylor PN |
| Source: |
Epilepsia, 2025 |
| Publisher Information: |
John Wiley and Sons Inc. |
| Publication Year: |
2025 |
| Collection: |
Newcastle University Library ePrints Service |
| Description: |
© 2025 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. Objective: Precise localization of epileptogenic tissue is critical for successful surgery in drug-resistant temporal lobe epilepsy (TLE) but is challenging in those requiring intracranial electroencephalography (iEEG). A range of modalities are used for localization, including magnetic resonance imaging (MRI) and EEG, which are typically integrated qualitatively by the clinical team. Methods: This study quantitatively performed retrospective analysis of three modalities in 40 individuals with TLE who underwent subsequent resective surgery: preoperative diffusion-weighted MRI, T1-weighted MRI, and iEEG. Brain abnormalities in gray matter (GM) volume, superficial white matter (SWM) mean diffusivity, and interictal iEEG band power were derived by comparison to 97 MRI controls and 247 subjects with iEEG. We hypothesized that combined abnormalities in GM and SWM could differentiate postsurgical outcomes and adding iEEG abnormalities would improve outcome differentiation. Results: MRI (union of GM and SWM) abnormalities were primarily concentrated in the ipsilateral hippocampus and inferior temporal regions. Resection of these abnormal regions effectively differentiated seizure-free outcomes (area under the curve [AUC] =.76, area under the precision–recall curve [AUPRC] =.78, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/309642; https://eprints.ncl.ac.uk/fulltext.aspx?url=309642/02DC478C-BEAD-4C71-BFE0-E6A2A28A1C82.pdf&pub_id=309642 |
| Availability: |
https://eprints.ncl.ac.uk/309642 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.61C1AAD0 |
| Database: |
BASE |