| Title: |
Restrictive filling pattern is associated with increased humoral activation and impaired exercise capacity in dilated cardiomyopathy |
| Authors: |
Patrianakos, Alexander P.; Parthenakis, Frangiskos I.; Papadimitriou, Evangelos A.; Diakakis, George F.; Tzerakis, Panagiotis G.; Nikitovic, Dragana; Vardas, Panos E. |
| Source: |
European Journal of Heart Failure ; volume 6, issue 6, page 735-743 ; ISSN 1388-9842 1879-0844 |
| Publisher Information: |
Wiley |
| Publication Year: |
2004 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objectives: Although heart failure (HF) is characterized by increased proinflammatory cytokines, natriuretic peptide levels and impaired exercise capacity, the effect of concomitant diastolic dysfunction on those parameters has not been adequately studied. Methods: We analyzed circulating levels of IL‐1, IL‐6, TNF‐α and its soluble receptors, sTNFRI and sTNFRII, Nt‐ANP and Nt‐BNP natriuretic peptides in 81 patients, aged 56±12 years, with non‐ischemic dilated cardiomyopathy (NIDC), LVEF 29.7±7.75% and functional NYHA class II‐III. An echocardiographic study and cardiopulmonary exercise test (CPE) were performed in all patients. Results: Patients were divided into restrictive (24 patients, group I) and non‐restrictive (57 patients, group II) groups, according to their transmitral‐filling pattern. No differences in LV dimensions or LVEF were found between the two groups. Group I showed increased levels of IL‐6 ( P =0.006), TNF‐α ( P =0.05), sTNFRII ( P =0.02), Nt‐ANP ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/j.ejheart.2003.11.013 |
| Availability: |
https://doi.org/10.1016/j.ejheart.2003.11.013; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.ejheart.2003.11.013; https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.ejheart.2003.11.013 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.61F62AB2 |
| Database: |
BASE |