| Title: |
Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms |
| Authors: |
Tanriverdi, Büşra; Gregory, David F; Olino, Thomas M; Ely, Timothy D; Harnett, Nathaniel G; van Rooij, Sanne J H; Lebois, Lauren A M; Seligowski, Antonia V; Jovanovic, Tanja; Ressler, Kerry J; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Kurz, Michael C; McGrath, Meghan E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Datner, Elizabeth M; Pearson, Claire; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sanchez, Leon D; Bruce, Steven E; Miller, Mark W; Pietrzak, Robert H; Joormann, Jutta; Barch, Deanna M; Pizzagalli, Diego A; Sheridan, John F; Smoller, Jordan W; Harte, Steven E; Elliott, James M; McLean, Samuel A; Kessler, Ronald C; Koenen, Karestan C; Stevens, Jennifer S; Murty, Vishnu P |
| Contributors: |
Emergency Medicine |
| Source: |
The Journal of neuroscience : the official journal of the Society for Neuroscience ; 42 ; 34 ; 6593 ; 604 ; United States |
| Publication Year: |
2023 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
arousal; fear; fMRI; hippocampus; trauma |
| Description: |
Hippocampal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat-sensitivity may interact with arousal responses to alter hippocampal reactivity, and further how these interactions relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma (N=116, 76 Female), we found that PTSD symptoms at 2-weeks were associated with decreased hippocampal responses to threat as assessed with functional magnetic resonance imaging (fMRI). Further, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed transient, high threat-related arousal, as assayed by an independently collected measure of Fear Potentiated Startle. Collectively, our finding suggests that development of PTSD is associated with threat-related decreases in hippocampal function, due to increases in fear-potentiated arousal. Significance Statement: Alterations in hippocampal function linked to threat-related arousal are reliably associated with post-traumatic stress disorder (PTSD); however, how these alterations relate to the sequelae of trauma-related symptoms is unknown. Prior models based on non-trauma samples suggest that arousal may impact hippocampal neurophysiology leading to maladaptive behavior. Here we show that decreased hippocampal threat sensitivity interacts with fear-potentiated startle to predict PTSD symptoms. Specifically, individuals with high fear-potentiated startle and low, transient hippocampal threat sensitivity showed the greatest PTSD symptomology. These findings bridge literatures of threat-related arousal and hippocampal function to better understand PTSD risk. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
JNeurosci; https://doi.org/10.1523/jneurosci.0911-21.2022; http://hdl.handle.net/20.500.14038/52752; The Journal of neuroscience : the official journal of the Society for Neuroscience |
| DOI: |
10.1523/JNEUROSCI.0911-21.2022 |
| Availability: |
https://doi.org/10.1523/JNEUROSCI.0911-21.2022; https://hdl.handle.net/20.500.14038/52752 |
| Rights: |
Authors grant JNeurosci a license to publish their work and copyright remains with the author. For articles published after 2014, the Society for Neuroscience (SfN) retains an exclusive license to publish the article for 6 months; after 6 months, the work becomes available to the public to copy, distribute, or display under the terms of the Creative Commons Attribution 4.0 International License (CC-BY). This license allows data and text mining, use of figures in presentations, and posting the article online, provided that the original article is credited. ; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.621A0268 |
| Database: |
BASE |