| Title: |
Vitamin D and Cardiovascular Disease: The “Good”, the “Bad”, and the “Unknown” |
| Authors: |
Giamundo D. M.; Morello M.; Pastena P.; Bernardi M.; Spadafora L.; Cacciatore S.; Perone F.; Caminiti G.; Sabouret P.; Cesaro A.; Di Muro F. M.; Golino M. |
| Contributors: |
Giamundo, D. M.; Morello, M.; Pastena, P.; Bernardi, M.; Spadafora, L.; Cacciatore, S.; Perone, F.; Caminiti, G.; Sabouret, P.; Cesaro, A.; Di Muro, F. M.; Golino, M. |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| Subject Terms: |
atherosclerosi; cardiovascular disease; heart failure; hypertension; vitamin D deficiency |
| Description: |
Vitamin D is a key regulator of calcium and phosphorus homeostasis; meanwhile, the dietary absence of vitamin D represents the most common nutritional deficiency worldwide. The discovery of vitamin D receptors and conversion enzymes within the cardiovascular system has fueled growing interest in the potential roles of vitamin D beyond bone health. Indeed, preclinical studies have suggested that vitamin D might regulate vascular tone and exert antifibrotic and anti-remodeling effects on the myocardium. Furthermore, a deficit in vitamin D has been associated with an increased risk of hypertension, atherosclerosis, and heart failure. These findings have prompted several interventional studies to investigate whether vitamin D supplementation can mitigate cardiovascular risk. However, current evidence regarding the cardiovascular benefits of vitamin D intake remains inconsistent and inconclusive. This review aims to provide a comprehensive overview of the “good”, the “bad”, and the “unknown” aspects of the relationship between vitamin D and cardiovascular disease. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41209105; info:eu-repo/semantics/altIdentifier/wos/WOS:001609430000002; volume:26; issue:10; journal:REVIEWS IN CARDIOVASCULAR MEDICINE; https://hdl.handle.net/11591/584270 |
| DOI: |
10.31083/RCM40001 |
| Availability: |
https://hdl.handle.net/11591/584270; https://doi.org/10.31083/RCM40001 |
| Accession Number: |
edsbas.6222EA78 |
| Database: |
BASE |