| Title: |
Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses |
| Authors: |
Moore,Amy; Kane,Eleanor; Teras,Lauren R; Machiela,Mitchell J; Arias,Joshua; Panagiotou,Orestis A; Monnereau,Alain; Doo,Nicole Wong; Wang,Zhaoming; Slager,Susan L; Vermeulen, Roel C H; Vajdic,Claire M; Smedby,Karin E; Spinelli,John J; Vijai,Joseph; Giles,Graham G; Link,Brian K; Arslan,Alan A; Nieters,Alexandra; Bracci,Paige M; Camp,Nicola J; Salles,Gilles; Cozen,Wendy; Hjalgrim,Henrik; De Vivo,Immaculata; Adami,Hans-Olov; Albanes,Demetrius; Becker,Nikolaus; Benavente,Yolanda; Bisanzi,Simonetta; Boffetta,Paolo; Brennan,Paul; Brooks-Wilson,Angela R; Canzian,Federico; Clavel,Jacqueline; Conde,Lucia; Cox,David G; Curtin,Karen; Foretova,Lenka; Ghesquières,Hervé; Glimelius,Bengt; Habermann,Thomas M; Hofmann,Jonathan N; Lan,Qing; Liebow,Mark; Lincoln,Anne; Maynadie,Marc; McKay,James; Melbye,Mads; Miligi,Lucia; Milne,Roger L; Molina,Thierry J; Morton,Lindsay M; North,Kari E; Offit,Kenneth; Padoan,Marina; Piro,Sara; Patel,Alpa V; Purdue,Mark P; Ravichandran,Vignesh; Riboli,Elio; Severson,Richard K; Southey,Melissa C; Staines,Anthony; Tinker,Lesley F; Travis,Ruth C; Wang,Sophia S; Weiderpass,Elisabete; Weinstein,Stephanie; Zheng,Tongzhang; Chanock,Stephen J; Rothman,Nathaniel; Birmann,Brenda M; Cerhan,James R; Berndt,Sonja I; Cancer; Circulatory Health; Planetary Health & Exposoom |
| Publication Year: |
2026 |
| Subject Terms: |
Journal Article |
| Description: |
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0020-7136 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/467570 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/467570 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6254F557 |
| Database: |
BASE |