| Title: |
RAMEN : Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood |
| Authors: |
Navarro‐Delgado, Erick I.; Czamara, Darina; Edwards, Karlie; Fu, Maggie P.; Merrill, Sarah M.; Konwar, Chaini; MacIsaac, Julie L.; Lin, C.-J. David; Mandhane, Piush; Simons, Elinor; Subbarao, Padmaja; Moraes, Theo J.; Lahti, Jari; Miller, Gregory E.; Binder, Elisabeth B.; Räikkönen, Katri; Turvey, Stuart E.; Korthauer, Keegan; Kobor, Michael S. |
| Contributors: |
Department of Psychology; Faculty of Medicine; HUS Gynecology and Obstetrics; Department of Obstetrics and Gynecology |
| Publisher Information: |
BioMed Central Ltd |
| Publication Year: |
2026 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Genetics; developmental biology; physiology; DNA methylation; DNA methylome variability; Gene-environment contribution; Gene-environment interaction; GxE; Multi-omics integration; Prenatal exposome; R package; Software |
| Description: |
Genetic variation and environmental exposures are amongst the main factors associated with inter-individual DNA methylation variability. However, the prevalence and genomic context of individual, additive, and interactive gene-environment effects remains unclear. We present RAMEN, an R package that dissects genome-exposome contributions to microarray Variably Methylated Loci using machine learning and statistical techniques. Analyzing cord blood samples from CHILD and PREDO (overall n = 1662), we identify genetic variants as key contributors to DNA methylation variability, usually in additive and interactive combinations with the environment. We provide a detailed catalogue of cord blood Variably Methylated Loci and the gene-environment contribution to their variability. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
This work was supported by BC Children's Hospital Research Institute Establishment Award (to K.K.). E.I.N.D. was funded by the Graduate Globalink Fellowship from MITACS, the Society to Cell Clyde Hertzman Memorial Fellowship from the Social Exposome Cluster, the Gertrude Langridge Graduate Scholarship in Medical Sciences, the Patrick David Campbell Graduate Fellowship, the Bank of Montreal Graduate Fellowship and the 4-Year PhD Fellowship from the University of British Columbia. The CHILD Cohort study was supported by core funding from The Allergy, Genes and Environment Network of Centres of Excellence (AllerGen NCE) and the Canadian Institutes of Health Research (CIHR); for further information visit childstudy.ca. CHILD epigenetic analysis at the University of British Columbia was funded by CIHR, AllerGen NCE and Genome Canada and Genome British Columbia ([274CHI]). S.E.T. holds a Tier 1 Canada Research Chair in Pediatric Precision Health and the Aubrey J. Tingle Professor of Pediatric Immunology. M.S.K. is the Canada Research Chair in Social Epigenetics and the Edwin S.H. Leong Chair in Healthy Aging - a UBC President's Excellence Chair. The PREDO study was supported by funding from the Academy of Finland, European Union's Horizon Europe research and innovation program under grant agreement No 101057390 (HappyMums), Helsinki Institute of Life Sciences (HiLife) Fellows Programme 2023-2024, and HUS VTR (A special Finnish state subsidy for health science research).; https://hdl.handle.net/10138/625456; 105024573848; 001636374200002 |
| Availability: |
https://hdl.handle.net/10138/625456 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.62B2144E |
| Database: |
BASE |