| Title: |
Genome-wide patterns of selection in 230 ancient Eurasians |
| Authors: |
Mathieson, Iain; Lazaridis, Iosif; Rohland, Nadin; Mallick, Swapan; Patterson, Nick; Roodenberg, Songül Alpaslan; Harney, Eadaoin; Stewardson, Kristin; Fernandes, Daniel; Novak, Mario; Sirak, Kendra; Gamba, Cristina; Jones, Eppie R.; Llamas, Bastien; Dryomov, Stanislav; Pickrell, Joseph; Arsuaga, Juan Luís; De Castro, José María Bermúdez; Carbonell, Eudald; Gerritsen, Fokke; Khokhlov, Aleksandr; Kuznetsov, Pavel; Lozano, Marina; Meller, Harald; Mochalov, Oleg; Moiseyev, Vyacheslav; Guerra, Manuel A.Rojo; Roodenberg, Jacob; Vergès, Josep Maria; Krause, Johannes; Cooper, Alan; Alt, Kurt W.; Brown, Dorcas; Anthony, David; Lalueza-Fox, Carles; Haak, Wolfgang; Pinhasi, Ron; Reich, David |
| Source: |
Nature |
| Publication Year: |
2015 |
| Collection: |
Australian National University: ANU Digital Collections |
| Description: |
Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height. ; Acknowledgements We thank P. de Bakker, J. Burger, C. Economou, E. Fornander, Q. Fu, F. Hallgren, K. Kirsanow, A. Mittnik, I. Olalde, A. Powell, P. Skoglund, S. Tabrizi and A. Tandon for discussions, suggestions about SNPs to include, or contribution to sample preparation or data curation. We thank S. Pääbo, M. Meyer, Q. Fu and B. Nickel for collaboration in developing the 1240k capture reagent. We thank J. M. V. Encinas and M. E. Prada for allowing us to resample La Braña 1. I.M. was supported by the Human Frontier Science Program LT001095/2014-L. C.G. was supported by the Irish Research Council for Humanities and Social Sciences (IRCHSS). F.G. was supported by a grant of the Netherlands Organization for Scientific Research, no. 380-62-005. A.K., P.K. and O.M. were supported by RFBR no. 15-06-01916 and RFH no. 15-11-63008 and O.M. by a state grant of the Ministry of Education and Science of the Russia Federation no. 33.1195.2014/k. J.K. was supported by ERC starting grant APGREID and DFG grant KR 4015/1-1. K.W.A. was supported by DFG grant AL 287 / 14-1. C.L.-F. was supported ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
PubMed:26595274; http://www.scopus.com/inward/record.url?scp=84951286136&partnerID=8YFLogxK; https://hdl.handle.net/1885/733753233; 84951286136 |
| DOI: |
10.1038/nature16152 |
| Availability: |
https://hdl.handle.net/1885/733753233; http://www.scopus.com/inward/record.url?scp=84951286136&partnerID=8YFLogxK; https://doi.org/10.1038/nature16152 |
| Rights: |
Publisher Copyright: © 2015 Macmillan Publishers Limited. All rights reserved. |
| Accession Number: |
edsbas.62E966FF |
| Database: |
BASE |