Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care: an Open-Label Pilot Study
| Title: | Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care: an Open-Label Pilot Study |
|---|---|
| Authors: | Settelmeier, Stephan; Rassaf, Tienush; Hendgen-Cotta, Ulrike B.; Stoffels, Ingo |
| Publication Year: | 2021 |
| Collection: | University of Duisburg-Essen: DuEPublico (Duisburg Essen Publications online) |
| Subject Terms: | ScholarlyArticle; ddc:610; Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Kardiologie und Angiologie; Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Dermatologie; nitric oxide -- NO -- acne vulgaris -- topical therapy -- skin ageing |
| Description: | Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved in the pathogenesis of multiple dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A novel NO-producing gel-formulation was tested beneficial in the treatment of acne vulgaris in an open-label pilot study using clinical evaluation scores. It showed a decrease of comedones and inflammatory pustulae and reduced the Global Acne Grading System score by 50% within eight weeks. In addition, we demonstrate a potential use as cosmetic agent where NO therapy leads to an increase of skin integrity and a reduction of skin ageing processes. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://doi.org/10.3390/cosmetics8010016 |
| DOI: | 10.3390/cosmetics8010016 |
| Availability: | https://doi.org/10.3390/cosmetics8010016; https://nbn-resolving.org/urn:nbn:de:hbz:464-20210416-114655-3; https://duepublico2.uni-due.de/receive/duepublico_mods_00074212; https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00074044/cosmetics_08_00016_Settelmeier_et_al.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.62FFE7D0 |
| Database: | BASE |