| Title: |
Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma |
| Authors: |
SIMIONI, PAOLO; TORMENE, DANIELA; SIMIONI P.; ROSING J; HACKENG TM |
| Contributors: |
Simioni, Paolo; Simioni, P.; Tormene, Daniela; Rosing, J; Hackeng, Tm |
| Publication Year: |
2010 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: |
BACKGROUND: Protein S and tissue factor pathway inhibitor (TFPI) act together in down-regulating coagulation. OBJECTIVE: To investigate the TFPI/protein S system in hereditary and acquired protein S deficiency. METHODS: Plasma antigen levels of protein S and full-length TFPI were determined in heterozygous type I protein S-deficient individuals (n=35), patients on oral anticoagulant treatment (OAT) (n=29), oral contraceptive (OC) users (n=10) and matched controls. Thrombin generation was determined using calibrated automated thrombography. RESULTS: Full-length TFPI levels were lower in type I protein S-deficient individuals (76.8+/-33.8%) than in age- and sex-matched controls (128.0+/-59.4%, P |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000273687600013; volume:8; firstpage:294; lastpage:300; numberofpages:7; journal:JOURNAL OF THROMBOSIS AND HAEMOSTASIS; https://hdl.handle.net/11577/2427890 |
| Availability: |
https://hdl.handle.net/11577/2427890 |
| Accession Number: |
edsbas.6337135 |
| Database: |
BASE |