Health economic impact of early versus delayed treatment of herpes simplex virus encephalitis in the UK
| Title: | Health economic impact of early versus delayed treatment of herpes simplex virus encephalitis in the UK |
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| Authors: | Defres, S; Navvuga, P; Moore, S; Hardwick, H; Easton, A; Michael, BD; Kneen, R; Griffiths, M; Medina-Lara, A; Solomon, T; Backman, R; Baker, G; Beeching, NJ; Breen, R; Brown, D; Cheyne, C; Carrol, ED; Davies, NWS; Eccles, M; Foy, R; Garcia-Finana, M; Granerod, J; Griem, J; Gummery, A; Harris, L; Hickey, H; Hill, H; Jacoby, A; Kierans, C; Kopelman, M; Lancaster, G; Levin, M; McDonald, R; Menson, E; Michael, B; Martin, N; Pennington, A; Pollard, A; Riley, J; Sadarangani, M; Salter, A; Tharmaratnam, K; Thornton, M; Vincent, A; Warlow, C; Barlow, G; Blanchard, T; Body, R; Boyd, G; Cebria-Prejan, L; Chadwick, D; Cooke, R; Crawford, P; Davies, B; Douthwaite, S; Emsley, H; Goldenberg, S; Graham, C; Green, S; Hawkins, C; Irish, D; Jeffrey, K; Jones, M; Keating, L; Keep, J; Larkin, S; Leita, M; Macallan, D; Minton, J; Mohandas, K; Moran, E; Muir, D; Pasztor, M; Reed, M; Stanley, P; Sutton, J; Thomas, P; Thwaites, G; Weir, J; Zuckerman, M |
| Publisher Information: | BMJ |
| Publication Year: | 2025 |
| Collection: | The University of Liverpool Repository |
| Description: | Objective Thanks to the introduction of recent national guidelines for treating herpes simplex virus (HSV) encephalitis, health outcomes have improved. This paper evaluates the health system costs and the health-related quality of life implications of these guidelines. Design and setting A sub-analysis of data from a prospective, multi-centre, observational cohort ENCEPH-UK study conducted across 29 hospitals in the UK from 2012 to 2015. Study participants Data for patients aged ≥16 years with a confirmed HSV encephalitis diagnosis admitted for treatment with aciclovir were collected at discharge, 3 and 12 months. Primary and secondary outcome measures Patient health outcomes were measured by the Glasgow outcome score (GOS), modified ranking score (mRS) and the EuroQoL; healthcare costs were estimated per patient at discharge from hospital and at 12 months follow-up. In addition, Quality Adjusted Life Years (QALYs) were calculated from the EQ-5D utility scores. Cost-utility analysis was performed using the NHS and Social Care perspective. Results A total of 49 patients were included; 35 were treated within 48 hours, € early' (median (IQR) 8.25 [3.7-20.5]) and 14 were treated after 48 hours € delayed' (median (IQR) 93.9 [66.7-100.1]). At discharge, 30 (86%) in the early treatment group had a good mRS outcome score (0-3) compared with 4 (29%) in the delayed group. According to GOS, 10 (29%) had a good recovery in the early treatment group, but only 1 (7%) in the delayed group. EQ-5D-3L utility value at discharge was significantly higher for early treatment (0.609 vs 0.221, p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2044-6055 |
| Relation: | https://livrepository.liverpool.ac.uk/3194809/1/Health%20economic%20impact%20of%20early%20versus%20delayed%20treatment%20of%20herpes%20simplex%20virus%20encephalitis%20in%20the%20UK.pdf; Collapse authors list. Defres, S orcid:0000-0002-4729-7505 , Navvuga, P, Moore, S orcid:0000-0001-8610-2806 , Hardwick, H, Easton, A, Michael, BD orcid:0000-0002-8693-8926 , Kneen, R, Griffiths, M, Medina-Lara, A, Solomon, T orcid:0000-0001-7266-6547 et al (show 73 more authors) , Backman, R, Baker, G, Beeching, NJ, Breen, R, Brown, D, Cheyne, C, Carrol, ED orcid:0000-0001-8357-7726 , Davies, NWS, Easton, A, Eccles, M, Foy, R, Garcia-Finana, M, Granerod, J, Griem, J, Gummery, A, Harris, L, Hickey, H, Hill, H, Jacoby, A, Kierans, C, Kopelman, M, Lancaster, G, Levin, M, McDonald, R, Medina-Lara, A, Menson, E, Michael, B, Martin, N, Pennington, A, Pollard, A, Riley, J, Sadarangani, M, Salter, A, Tharmaratnam, K orcid:0000-0002-8255-9822 , Thornton, M, Vincent, A, Warlow, C, Barlow, G, Blanchard, T, Body, R, Boyd, G, Cebria-Prejan, L, Chadwick, D, Cooke, R, Crawford, P, Davies, B, Douthwaite, S, Emsley, H, Goldenberg, S, Graham, C, Green, S, Hawkins, C, Irish, D, Jeffrey, K, Jones, M, Keating, L, Keep, J, Larkin, S, Leita, M, Macallan, D, Minton, J, Mohandas, K, Moran, E, Muir, D, Pasztor, M, Reed, M, Solomon, T, Stanley, P, Sutton, J, Thomas, P, Thwaites, G, Weir, J and Zuckerman, M (2025) Health economic impact of early versus delayed treatment of herpes simplex virus encephalitis in the UK BMJ Open, 15 (9). e088473-. ISSN 2044-6055, 2044-6055 |
| DOI: | 10.1136/bmjopen-2024-088473 |
| Availability: | https://livrepository.liverpool.ac.uk/3194809/; https://doi.org/10.1136/bmjopen-2024-088473; https://livrepository.liverpool.ac.uk/3194809/1/Health%20economic%20impact%20of%20early%20versus%20delayed%20treatment%20of%20herpes%20simplex%20virus%20encephalitis%20in%20the%20UK.pdf |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.63597FE4 |
| Database: | BASE |