| Title: |
A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease |
| Authors: |
Alvergne, A; Kountourides, G; Argentieri, MA; Agyen, L; Rogers, N; Knight, D; Sharp, GC; Maybin, JA; Olszewska, Z |
| Publisher Information: |
Cell Press |
| Publication Year: |
2023 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. Our objectives were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease. We performed a secondary analysis of a retrospective online survey conducted in the UK in March 2021. In pre-menopausal vaccinated participants (n=4,989), 18% reported menstrual cycle changes after their first COVID-19 vaccine injection. The prevalence of reporting any menstrual changes was higher for women who smoke, have a history of COVID-19 disease, or are not using oestradiol-containing contraceptives. In a second sample including both vaccinated and unvaccinated participants (n=12,579), COVID-19 vaccination alone was not associated with abnormal menstrual cycle parameters while a history of COVID-19 disease was associated with an increased risk of reporting heavier bleeding, ‘missed’ periods and inter-menstrual bleeding. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1016/j.isci.2023.106401 |
| DOI: |
10.1016/j.isci.2023.106401 |
| Availability: |
https://doi.org/10.1016/j.isci.2023.106401; https://ora.ox.ac.uk/objects/uuid:45e28ac4-1ac6-40e2-941f-46e4e3a6ab58 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.6378BD6 |
| Database: |
BASE |