| Title: |
The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants |
| Authors: |
Aparicio, Lucas S; Huang, Qi-Fang; Melgarejo, Jesus D; Wei, Dong-Mei; Thijs, Lutgarde; Wei, Fang-Fei; Gilis-Malinowska, Natasza; Sheng, Chang-Sheng; Boggia, José; Niiranen, Teemu J; Odili, Augustine N; Stolarz-Skrzypek, Katarzyna; Barochiner, Jessica; Ackermann, Daniel; Kawecka-Jaszcz, Kalina; Tikhonoff, Valérie; Zhang, Zhen-Yu; Casiglia, Edoardo; Narkiewicz, Krzysztof; Filipovský, Jan; Schutte, Aletta E; Yang, Wen-Yi; Jula, Antti M; Woodiwiss, Angela J; Bochud, Murielle; Norton, Gavin R; Wang, Ji-Guang; Li, Yan; Staessen, Jan A; Aparicio, L S; Barochiner, J; Wei, D-M; Melgarejo, J D; Thijs, L; Staessen, J A; Wei, F-F; Yang, W-Y; Zhang, Z-Y; An, D W; Cheng, Y B; Guo, Q H; Huang, J F; Huang, Q F; Li, Y; Sheng, C S; Wang, J G; Filipovský, J; Seidlerová, J; Juhanoja, E P; Jula, A M |
| Contributors: |
Internal Medicine Service, Hospital Italiano de Buenos Aires; European Union; European Research Council; European Research Area Net for Cardiovascular Diseases; National Natural Science Foundation of China; Ministry of Science and Technology; Shanghai Commissions of Science and Technology; Shanghai Municipal Health Commission; Charles University Research Fund; Academy of Finland; Paavo Nurmi Foundation; Urmas Pekkala Foundation; Hospital District of South-Western Finland; Foundation for Polish Science; South African Medical Research Council; South African Research Chairs Initiative; Department of Science and Technology and National Research Foundation of South Africa; UK Medical Research Council; Asociación Española Primera en Salud; Swiss National Science Foundation |
| Source: |
American Journal of Hypertension ; volume 35, issue 1, page 54-64 ; ISSN 0895-7061 1941-7225 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2021 |
| Description: |
OBJECTIVE To address to what extent central hemodynamic measurements, improve risk stratification, and determine outcome-based diagnostic thresholds, we constructed the International Database of Central Arterial Properties for Risk Stratification (IDCARS), allowing a participant-level meta-analysis. The purpose of this article was to describe the characteristics of IDCARS participants and to highlight research perspectives. METHODS Longitudinal or cross-sectional cohort studies with central blood pressure measured with the SphygmoCor devices and software were included. RESULTS The database included 10,930 subjects (54.8% women; median age 46.0 years) from 13 studies in Europe, Africa, Asia, and South America. The prevalence of office hypertension was 4,446 (40.1%), of which 2,713 (61.0%) were treated, and of diabetes mellitus was 629 (5.8%). The peripheral and central systolic/diastolic blood pressure averaged 129.5/78.7 mm Hg and 118.2/79.7 mm Hg, respectively. Mean aortic pulse wave velocity was 7.3 m per seconds. Among 6,871 participants enrolled in 9 longitudinal studies, the median follow-up was 4.2 years (5th–95th percentile interval, 1.3–12.2 years). During 38,957 person-years of follow-up, 339 participants experienced a composite cardiovascular event and 212 died, 67 of cardiovascular disease. CONCLUSIONS IDCARS will provide a unique opportunity to investigate hypotheses on central hemodynamic measurements that could not reliably be studied in individual studies. The results of these analyses might inform guidelines and be of help to clinicians involved in the management of patients with suspected or established hypertension. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ajh/hpab139 |
| DOI: |
10.1093/ajh/hpab139/40569848/hpab139.pdf |
| Availability: |
https://doi.org/10.1093/ajh/hpab139; http://academic.oup.com/ajh/advance-article-pdf/doi/10.1093/ajh/hpab139/40569848/hpab139.pdf; https://academic.oup.com/ajh/article-pdf/35/1/54/54256826/hpab139.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.638EAC22 |
| Database: |
BASE |