| Title: |
Hepatitis B Surface Antibody Clearance After Vaccination in People With HIV |
| Authors: |
Ursenbach, Axel; Séverac, François; Chahard, Archia; Alfaiate, Dulce; Bani-Sadr, Firouzé; Hocqueloux, Laurent; Rey, David; Chirouze, C; Bouiller, K; Bozon, F; Brunel, A S; Hustache-Mathieu, L; Lagoutte, J; Lepiller, Q; Marty-Quinternet, S; Pépin-Puget, L; Rosolen, B; Tissot, N; Lebreton, C; Bohard, L; Jaffuel, S; Ansart, S; Quintric, Y; Rezig, S; Quaesaet, L; Gazeau, P; Jacomet, C; Mrozek, N; Theis, C; Vidal, M; Richaud, C; Corbin, V; Benelhadj, A; Zaghdoudi, A; Aumeran, C; Baud, O; Berthommier, M; Charles, M; Durand, C; Coban, D; Mirand, A; Brebion, A; Chabrolles, H; Perruche, O; Creuzet, E; Henquell, C; Lamaury, I; Baronnet, G; Bissuel, F; Boulard, F |
| Source: |
Open Forum Infectious Diseases ; volume 13, issue 1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background People with HIV (PWH) are at higher risk of developing chronic hepatitis B, and therefore vaccination against HBV is highly recommended. Clearance of hepatitis B surface antibody (anti-HBs) over time is poorly described in PWH. Methods We retrospectively included vaccinated PWH with anti-HBs ≥10 IU/L from the French Dat’AIDS database. Those with a cured hepatitis B were excluded. For each participant, all anti-HBs levels were collected until March 2024. Anti-HBs peak was defined as the highest anti-HBs value and corresponded to entry into the analysis. Factors associated with anti-HBs clearance below 10 IU/L were identified using a multivariable Cox model. Results 11 082 PWH were included, 4480 had peak anti-HBs levels between 10 and 99 IU/L, 3268 between 100 and 499 IU/L, 1205 between 500 and 999 IU/L, and 2129 ≥ 1000 IU/L. Median follow-up was 3.8 [1.6, 7.1] years. Antibody clearance over time was similar in the three groups with peak anti-HBs ≥100 IU/L, and significantly slower than in the group with anti-HBs |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf754 |
| DOI: |
10.1093/ofid/ofaf754/65835808/ofaf754.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaf754; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaf754/65835808/ofaf754.pdf; https://academic.oup.com/ofid/article-pdf/13/1/ofaf754/65835808/ofaf754.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.6396DE3D |
| Database: |
BASE |