| Title: |
A non-canonical lymphoblast in refractory childhood T-cell leukaemia. |
| Authors: |
Lim, Bram SJ; Whitfield, Holly J; Trinh, Mi K; Bloye, Gianna; Thomas, Rebecca; Anderson, Nathaniel D; Wenger, Anna; Hodder, Angus; Treger, Taryn D; Lee-Six, Henry; Coorens, Tim HH; Parks, Conor; Ogbonnah, Toochi; Pölönen, Petri; Mullighan, Charles G; Teachey, David T; Xu, Jason; Tan, Kai; Hagleitner, Melanie; Kester, Lennart; van Leeuwen, Frank N; Beattie, Gordon; Mansour, Marc R; Williams, Owen; Bartram, Jack; Adams, Stuart; Jardine, Laura; Behjati, Sam; O'Connor, David |
| Publisher Information: |
Springer Nature; //doi.org/10.1038/s41467-025-65049-8 |
| Publication Year: |
2025 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Humans; Child; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Male; Female; Preschool; Adolescent; Single-Cell Analysis; Prognosis; Drug Resistance; Neoplasm; Infant |
| Description: |
Acknowledgements: Some samples and data used in this study were provided by the Children’s Cancer and Leukaemia Group (CCLG) Tissue Bank (now part of VIVO Biobank), supported by Cancer Research UK and Blood Cancer UK (Grant no. CRCPSC-Dec21\100003). We are indebted to the children and their families who participated in this research. This study was funded by the Wellcome Trust (institutional grant, 108413/A/15/D, and personal fellowship to S.B.) and Cancer Research UK (Clinician Scientist Fellowship funding to D.O’C.). Further funding from Cancer Research UK and Children with Cancer via a Children and Young People’s Innovation Award facilitated additional sample collection and analysis through the REVEALL project. Work done at the Cancer Research UK City of London Centre Single Cell Genomics Facility and University College London Cancer Institute Bioinformatics Hub was supported by the Cancer Research UK City of London Centre Award (CTRQQR-2021/100004). We received additional funding from the Harley Staples Cancer Trust, the Agency for Science, Technology and Research (personal fellowship to B.S.J.L.), the Wenner-Gren Foundations (personal fellowship to A.W.), the Pessoa de Araujo family (personal fellowship to A.H.), The Little Princess Trust (personal fellowship to T.D.T.), the EMBO long-term fellowship (ALTF 172-2022, personal fellowship to T.H.H.C.), the National Institutes of Health Gabriella Miller Kids First Pediatric Research (X01HD100702, D.T.T.) and the Great Ormond Street Children’s Charity (professorship to M.R.M.). This research was supported by the NIHR GOSH Biomedical Research Centre and NIHR Cambridge Biomedical Research Centre (NIHR203312). The views expressed are those of the authors and not necessarily those of the NHS, NIHR or Department of Health. ; Refractory cancers may arise either through the acquisition of resistance mechanisms or represent distinct disease states. The origin of childhood T-cell acute lymphoblastic leukaemia (T-ALL) that does not respond to initial treatment, i.e. ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; text/xml; application/zip |
| Language: |
English |
| Relation: |
65049; https://www.repository.cam.ac.uk/handle/1810/392349 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/392349 |
| Accession Number: |
edsbas.63D6D06A |
| Database: |
BASE |