| Title: |
Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study |
| Authors: |
Bermingham, Kate M.; Mazidi, Mohsen; Franks, Paul w.; Maher, Tyler; Valdes, Ana m.; Linenberg, Inbar; Wolf, Jonathan; Hadjigeorgiou, George; Spector, Tim d.; Menni, Cristina; Ordovas, Jose m.; Berry, Sarah e.; Hall, Wendy l. |
| Source: |
Bermingham, K M, Mazidi, M, Franks, P W, Maher, T, Valdes, A M, Linenberg, I, Wolf, J, Hadjigeorgiou, G, Spector, T D, Menni, C, Ordovas, J M, Berry, S E & Hall, W L 2023, 'Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study', Nutrients, vol. 15, no. 11, 2638. https://doi.org/10.3390/nu15112638 |
| Publication Year: |
2023 |
| Collection: |
King's College, London: Research Portal |
| Description: |
Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2072-6643 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/2072-6643 |
| DOI: |
10.3390/nu15112638 |
| Availability: |
https://kclpure.kcl.ac.uk/portal/en/publications/13fcc511-13d8-465b-8949-22c9c8984f92; https://doi.org/10.3390/nu15112638; https://www.scopus.com/pages/publications/85161382348 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.64187D87 |
| Database: |
BASE |