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Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial

Title: Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial
Authors: Szarek, Michael; White, Harvey D.; Schwartz, Gregory G.; Alings, Marco; Bhatt, Deepak L.; Bittner, Vera A.; Diaz, Rafael; Edelberg, Jay M.; Goodman, Shaun G.; Hanotin, Corinne; Harrington, Robert A.; Jukema, J. Wouter; Kimura, Takeshi; Kiss, Robert Gabor; Lecorps, Guillaume; Mahaffey, Kenneth W.; Moryusef, Angele; Pordy, Robert; Roe, Matthew T.; Tricoci, Pierluigi; Xavier, Denis; Zeiher, Andreas M.; Steg, Gabriel; Steg, Ph Gabriel; Sasiela, William J.; Tamby, Jean-Francois; Aylward, Philip E.; Drexel, Heinz; Sinnaeve, Peter; Dilic, Mirza; Gotcheva, Nina N.; Prieto, Juan-Carlos; Yong, Huo; Lopez-Jaramillo, Patricio; Pecin, Ivan; Reiner, Zeljko; Ostadal, Petr; Poulsen, Steen Hvitfeldt; Viigimaa, Margus; Nieminen, Markku S.; Danchin, Nicolas; Chumburidze, Vakhtang; Marx, Nikolaus; Liberopoulos, Evangelos; Valdovinos, Pablo Carlos Montenegro; Tse, Hung-Fat; Zahger, Doron; Valgimigli, Marco; Kim, Hyo Soo; Kim, Sang-Hyun; Kedev, Sasko; Erglis, Andrejs; Laucevicius, Aleksandras; Yusoff, Khalid; Lopez, Ramos; Ramos Lopez, Gabriel Arturo; Halvorsen, Sigrun; Correa Flores, Roger M.; Sy, Rody G.; Budaj, Andrzej; Morais, Joao; Dorobantu, Maria; Karpov, Yuri; Ristic, Arsen D.; Chua, Terrance; Murin, Jan; Fras, Zlatko; Dalby, Anthony J.; Tunon, Jose; de Silva, H. Asita; Hagstrom, Emil; Muller, Christian; Chiang, Chern-En; Sritara, Piyamitr; Guneri, Sema; Parkhomenko, Alexander; Ray, Kausik K.; Moriarty, Patrick M.; Chaitman, Bernard; Kelsey, Sheryl F.; Olsson, Anders G.; Rouleau, Jean-Lucien; Simoons, Maarten L.; Alexander, Karen; Meloni, Chiara; Rosenson, Robert; Sijbrands, Eric J.G.; Alexander, John H.; Armaganijan, Luciana; Bagai, Akshay; Bahit, Maria Cecilia; Brennan, J. Matthew; Clifton, Shaun; DeVore, Adam D.; Deloatch, Shalonda; Dickey, Sheila; Dombrowski, Keith; Ducrocq, Gregory; Eapen, Zubin; Endsley, Patricia; Eppinger, Arleen; Harrison, Robert W.; Hess, Connie Ng; Hlatky, Mark A.; Jordan, Joseph Dedrick; Knowles, Joshua W.; Kolls, Bradley J.; Kong, David F.; Leonardi, Sergio; Lillis, Linda; Maron, David J.; Marcus, Jill; Mathews, Robin; Mehta, Rajendra H.; Mentz, Robert J.; Moreira, Humberto Graner; Patel, Chetan B.; Pereira, Sabrina Bernardez; Perkins, Lynn; Povsic, Thomas J.; Puymirat, Etienne; Jones, William Schuyler; Shah, Bimal R.; Sherwood, Matthew W.; Stringfellow, Kenya; Sujjavanich, Darin; Toma, Mustafa; Van Diepen, Sean F.P.; Wilson, Matthew D.; Yan, Andrew Tze-Kay; Lopes, Renato D.; Trotter, Charlene; Schiavi, Lilia B.; Garrido, Marcelo; Alvarisqueta, Andres F.; Sassone, Sonia A.; Bordonava, Anselmo P.; Alves De Lima, Alberto E.; Schmidberg, Jorge M.; Duronto, Ernesto A.; Caruso, Orlando C.; Novaretto, Leonardo P.; Angel Hominal, Miguel; Montana, Oscar R.; Caccavo, Alberto; Gomez Vilamajo, Oscar A.; Lorenzatti, Alberto J.; Cartasegna, Luis R.; Paterlini, Gustavo A.; Mackinnon, Ignacio J.; Caime, Guillermo D.; Amuchastegui, Marcos; Salomone, Rodolfo; Codutti, Oscar R.; Jure, Horacio O.; Bono, Julio O.E.; Hrabar, Adrian D.; Vallejos, Julio A.; Ahuad Guerrero, Rodolfo A.; Novoa, Federico; Patocchi, Cristian A.; Zaidman, Cesar J.; Giuliano, Maria E.; Dran, Ricardo D.; Vico, Marisa L.; Carnero, Gabriela S.; Guzman, Pablo N.; Medrano Allende, Juan C.; Garcia Brasca, Daniela F.; Bustamante Labarta, Miguel H.; Nani, Sebastian; Blumberg, Eduardo D.S.; Colombo, Hugo R.; Liberman, Alberto; Luciardi, Hector L.; Waisman, Gabriel D.; Berli, Mario A.; Duran, Ruben O. Garcia; Cestari, Horacio G.; Luquez, Hugo A.; Giordano, Jorge A.; Saavedra, Silvia S.; Zapata, Gerardo; Costamagna, Osvaldo; Llois, Susana; Waites, Jonathon H.; Collins, Nicholas; Soward, Allan; Hii, Chris L.S.; Shaw, James; Arstall, Margaret A.; Horowitz, John; Rogers, James F.; Colquhoun, David; Oqueli Flores, Romulo E.; Roberts-Thomson, Philip; Raffel, Owen; Lehman, Sam J.; Aroney, Constantine; Coverdale, Steven G.M.; Garrahy, Paul J.; Starmer, Gregory; Sader, Mark; Carroll, Patrick A.; Dick, Ronald; Zweiker, Robert; Hoppe, Uta; Huber, Kurt; Berger, Rudolf; Weidinger, Franz; Faes, Dirk; Hermans, Kurt; Pirenne, Bruno; Leone, Attilio; Hoffer, Etienne; Vrolix, Mathias C.M.; De Wolf, Luc; Wollaert, Bart; Castadot, Marc; Dujardin, Karl; Beauloye, Christophe; Vervoort, Geert; Striekwold, Harry; Convens, Carl; Roosen, John; Barbato, Emanuele; Claeys, Marc; Cools, Frank; Terzic, Ibrahim; Barakovic, Fahir; Midzic, Zlatko; Pojskic, Belma; Fazlibegovic, Emir; Durak-Nalbantic, Azra; Vulic, Dusko; Muslibegovic, Adis; Goronja, Boris; Reis, Gilmar; Sousa, Luciano; Nicolau, Jose C.; Giorgeto, Flavio E.; Silva, Ricardo P.; Maia, Lilia Nigro; Rech, Rafael; Rossi, Paulo R.F.; Cerqueira, Maria Jose A.G.; Duda, Norberto; Kalil, Renato; Kormann, Adrian; Abrantes, Jose Antonio M.; Pimentel Filho, Pedro; Soggia, Ana Priscila; de Santos, Mayler O.N.; Neuenschwander, Fernando; Bodanese, Luiz C.; Michalaros, Yorghos L.; Eliaschewitz, Freddy G.; Vidotti, Maria H.; Leaes, Paulo E.; Botelho, Roberto V.; Kaiser, Sergio; Fernandes Manenti, Euler Roberto F.; Precoma, Dalton B.; Moura Jorge, Jose C.; Silva, Pedro G.M. de B.; Silveira, Jose A.; Saporito, Wladmir; Marin Neto, Jose A.; Feitosa, Gilson S.; Ritt, Luiz Eduardo F.; de Souza, Juliana A.; Costa, Fernando; Souza, Weimar K.SB.; Reis, Helder J.L.; Machado, Leandro; Aidar Ayoub, Jose Carlos; Todorov, Georgi V.; Nikolov, Fedya P.; Velcheva, Elena S.; Tzekova, Maria L.; Benov, Haralambi O.; Petranov, Stanislav L.; Tumbev, Haralin S.; Shehova-Yankova, Nina S.; Markov, Dimitar T.; Raev, Dimitar H.; Mollov, Mihail N.; Kichukov, Kostadin N.; Ilieva-Pandeva, Katya A.; Ivanova, Raya; Mincheva, Valentina M.; Lazov, Petar V.; Dimov, Bojidar I.; Senaratne, Manohara; Stone, James; Kornder, Jan; Pearce, Stephen; Dion, Danielle; Savard, Daniel; Pesant, Yves; Pandey, Amritanshu; Robinson, Simon; Gosselin, Gilbert; Vizel, Saul; Hoag, Gordon; Bourgeois, Ronald; Morisset, Anne; Sabbah, Eric; Sussex, Bruce; Kouz, Simon; MacDonald, Paul; Diaz, Ariel; Michaud, Nicolas; Fell, David; Leung, Raymond; Vuurmans, Tycho; Lai, Christopher; Nigro, Frank; Davies, Richard; Nogareda, Gustavo; Vijayaraghavan, Ram; Ducas, John; Lepage, Serge; Mehta, Shamir; Cha, James; Dupuis, Robert; Fong, Peter; Rodes-Cabau, Josep; Fadlallah, Hussein; Cleveland, David; Thao, Huynh; Bata, Iqbal; Hameed, Adnan; Pincetti, Cristian; Potthoff, Sergio; Prieto, Juan C.; Acevedo, Monica; Aguirre, Arnoldo; Vejar, Margarita; Yanez, Mario; Araneda, Guillermo; Fernandez, Mauricio; Perez, Luis; Varleta, Paola; Florenzano, Fernando; Huidobro, Laura; Raffo, Carlos A.; Olivares, Claudia; Nahuelpan, Leonardo; Montecinos, Humberto; Chen, Jiyan; Dong, Yugang; Huang, Weijian; Wang, Jianzhong; Huang, Shi'An; Yao, Zhuhua; Li, Xiang; Cui, Lan; Lin, Wenhua; Sun, Yuemin; Wang, Jingfeng; Li, Jianping; Zhang, Xuelian; Zhu, Hong; Chen, Dandan; Huang, Lan; Dong, Shaohong; Su, Guohai; Xu, Biao; Su, Xi; Cheng, Xiaoshu; Lin, Jinxiu; Zong, Wenxia; Li, Huanming; Feng, Yi; Xu, Dingli; Yang, Xinchun; Ke, Yuannan; Lin, Xuefeng; Zhang, Zheng; Zheng, Zeqi; Luo, Zhurong; Chen, Yundai; Ding, Chunhua; Zheng, Yang; Li, Xiaodong; Peng, Daoquan; Li, Ying; Wei, Meng; Liu, Shaowen; Yu, Yihua; Qu, Baiming; Jiang, Weihong; Zhou, Yujie; Zhao, Xingsheng; Yuan, Zuyi; Guo, Ying; Xu, Xiping; Shi, Xubo; Ge, Junbo; Fu, Guosheng; Bai, Feng; Fang, Weiyi; Shou, Xiling; Yang, Xiangjun; Wang, Jian'An; Sun, Yingxian; Lu, Qinghua; Zhang, Ruiyan; Zhu, Jianhua; Xu, Yizhou; Fan, Zhongcai; Li, Tianchang; Wu, Chun; Jaramillo, Nicolas; Vallejo, Gregorio Sanchez; Botia, Diana C. Luna; Lopez, Rodrigo Botero; De Salazar, Dora I. Molina; Bonfanti, Alberto J. Cadena; Higuera, Juan Diego; Silva, Sandra I. Barrera; Lozada, Henry J. Garcia; Arroyo, Julian A. Coronel; Mendoza, Jose L. Accini; Ruiz, Ricardo L. Fernandez; Jatin, Fernando G. Manzur; Herazo, Aristides Sotomayor; Parada, Jeffrey Castellanos; Triana, Miguel A. Urina; Strozzi, Maja; Car, Sinisa; Milicic, Davor; Bencic, Martina Lovric; Pintaric, Hrvoje; Prvulovic, Deiti; Sikic, Jozica; Persic, Viktor; Mileta, Dean; Stambuk, Kresimir; Zdravko, Babic; Tomulic, Vjekoslav; Krstulovic, Stanka Mejic; Starcevic, Boris; Spinar, Jindrich; Horak, David; Stasek, Josef; Alan, David; Machova, Vilma; Linhart, Ales; Novotny, Vojtech; Kaucak, Vladimir; Rokyta, Richard; Naplava, Robert; Coufal, Zdenek; Adamkova, Vera; Podpera, Ivo; Zizka, Jiri; Motovska, Zuzana; Marusincova, Ivana; Svab, Premysl; Heinc, Petr; Kuchar, Jiri; Povolny, Petr; Matuska, Jiri; Raungaard, Bent; Clemmensen, Peter; Bang, Lia E.; May, Ole; Bottcher, Morten; Hove, Jens D.; Frost, Lars; Gislason, Gunnar; Larsen, John; Johansen, Peter Betton; Hald, Flemming; Jeppesen, Jorgen; Nielsen, Tonny; Kristensen, Kjeld S.; Walichiewicz, Piotr Maria; Lomholdt, Jens D.; Klausen, Ib C.; Nielsen, Peter Kaiser; Davidsen, Flemming; Videbaek, Lars; Soots, Mai; Vahula, Veiko; Hedman, Anu; Soopold, Ullar; Martsin, Kaja; Kristjan, Arved; Taskinen, Marja-Riitta; Porthan, Kimmo; Airaksinen, Juhani K.; Juonala, Markus; Kiviniemi, Tuomas; Vikman, Saila; Posio, Pirjo; Taurio, Jyrki; Huikuri, Heikki; Kaikkonen, Kari; Coste, Pierre; Ferrari, Emile; Morel, Olivier; Montalescot, Gilles; Barone-Rochette, Gilles; Mansourati, Jacques; Cottin, Yves; Leclercq, Florence; Belhassane, Abdelkader; Delarche, Nicolas; Boccara, Franck; Paganelli, Franck; Clerc, Jerome; Schiele, Francois; Aboyans, Victor; Probst, Vincent; Berland, Jacques; Lefevre, Thierry; Citron, Bernard; Khintibidze, Irakli; Shaburishvili, Tamaz; Pagava, Zurab; Ghlonti, Ramaz; Lominadze, Zaza; Khabeishvili, George; Hemetsberger, Rayyan; Rauch-Kroehnert, Ursula; Stratmann, Matthias; Appel, Karl-Friedrich; Schmidt, Ekkehard; Omran, Heyder; Stellbrink, Christoph; Dorsel, Thomas; Lianopoulos, Emmanouil; Marx, Roger; Zirlik, Andreas; Schellenberg, Detlev; Heitzer, Thomas; Laufs, Ulrich; Gielen, Stephan; Winkelmann, Bernhard; Behrens, Steffen; Sydow, Karsten; Simonis, Gregor; Muenzel, Thomas; Werner, Nikos; Leggewie, Stefan; Boecker, Dirk; Braun-Dullaeus, Ruediger; Toursarkissian, Nicole; Jeserich, Michael; Weissbrodt, Matthias; Schaeufele, Tim; Weil, Joachim; Voeller, Heinz; Waltenberger, Johannes; Natour, Mohammed; Schmitt, Susanne; Steiner, Stephan; Heidenreich, Lothar; Gremmler, Uwe; Killat, Holger; Rieker, Werner; Patsilinakos, Sotiris; Kartalis, Athanasios; Manolis, Athanassios; Sionis, Dimitrios; Skoumas, Ioannis; Athyros, Vasilios; Vardas, Panagiotis; Parthenakis, Frangkiskos; Alexopoulos, Dimitrios; Hahalis, Georgios; Lekakis, John; Hatzitolios, Apostolos; Ovando, Sergio R. Fausto; Benecke, Juan L. Arango; De Leon, Edgar R. Rodriguez; Yan, Bryan P.Y.; Siu, David C.W.; Turi, Tibor; Merkely, Bela; Ungi, Imre; Lupkovics, Geza; Nagy, Lajos; Katona, Andras; Edes, Istvan; Muller, Gabor; Horvath, Ivan; Kapin, Tibor; Falukozy, Jozsef; Kumbla, Mukund; Sandhu, Manjinder; Annam, Sharath; Proddutur, Naveen Reddy; Premchand, Rajendra K.; Mahajan, Ajaykumar; Abhyanakar, Atul D.; Kerkar, Prafulla; Govinda, Ravishankar A.; Oomman, Abraham; Sinha, Dhurjati; Patil, Sachin N.; Kahali, Dhiman; Sawhney, Jitendra; Joshi, Abhijeet B.; Chaudhary, Sanjeev; Harkut, Pankaj; Guha, Santanu; Porwal, Sanjay; Jujjuru, Srimannarayana; Pothineni, Ramesh B.; Monteiro, Minguel R.; Khan, Aziz; Iyengar, Shamanna S.; Grewal, Jasprakash Singh; Chopda, Manoj; Fulwani, Mahesh C.; Patange, Aparna; Chopra, Vijay K.; Goyal, Naresh K.; Shinde, Rituparna; Manakshe, Gajendra V.; Patki, Nitin; Sethi, Sumeet; Munusamy, Vengatesh; Karna, Sunil; Adhyapak, Srilakshmi; Pandurangi, Ulhas; Mathur, Rishabh; Kalashetti, Suhas; Bhagwat, Ajit; Raghuraman, Bagirath; Yerra, Shiv Kumar; Bhansali, Prasant; Borse, Rohidas; Das, Srihari; Abdullakutty, Jabir; Saathe, Shireesh; Palimkar, Priya; Abdullkutty, Jabir; Sathe, Shireesh; Atar, Shaul; Shechter, Michael; Mosseri, Morris; Arbel, Yaron; Lotan, Chaim; Rosenschein, Uri; Katz, Amos; Henkin, Yaakov; Francis, Adi; Klutstein, Marc; Nikolsky, Eugenia; Turgeman, Yoav; Halabi, Majdi; Kornowski, Ran; Jonas, Michael; Amir, Offer; Rozenman, Yoseph; Fuchs, Shmuel; Hussein, Osamah; Gavish, Dov; Vered, Zvi; Caraco, Yoseph; Elias, Mazen; Tov, Naveh; Lishner, Michael; Elias, Nizar; Piovaccari, Giancarlo; De Pellegrin, Annamaria; Guardigli, Gabriele; Licciardello, Giovanni; Auguadro, Carla; Cuccia, Claudio; Salvioni, Alessandro; Musumeci, Giuseppe; Calabro, Paolo; Novo, Salvatore; Faggiano, Pompilio; De Cesare, Nicoletta B.; Berti, Sergio; Cavallini, Claudio; Puccioni, Enrico; Galvani, Marcello; Tespili, Maurizio; Piatti, Piermarco; Palvarini, Michela; De Luca, Giuseppe; Violini, Roberto; De Leo, Alessandro; Filardi, Pasquale Perrone; Ferratini, Maurizio; Ricca, Vittorio; Dai, Kazuoki; Kamiya, Haruo; Ando, Kenji; Takeda, Yoshihiro; Morino, Yoshihiro; Hata, Yoshiki; Kimura, Kazuo; Kishi, Koichi; Michishita, Ichiro; Uehara, Hiroki; Higashikata, Toshinori; Hirayama, Atsushi; Hirooka, Keiji; Sakagami, Satoru; Taguchi, Shuichi; Koike, Akihiro; Fujinaga, Hiroyuki; Koba, Shinji; Kozuma, Ken; Kawasaki, Tomohiro; Ono, Yujiro; Shimizu, Masatoshi; Katsuda, Yousuke; Wada, Atsuyuki; Shinke, Toshiro; Ako, Junya; Fujii, Kenshi; Takahashi, Toshiyuki; Sakamoto, Tomohiro; Furukawa, Yutaka; Sugino, Hiroshi; Mano, Toshiaki; Utsu, Noriaki; Ito, Kashima; Haraguchi, Takuya; Ueda, Yasunori; Nishibe, Akira; Fujimoto, Kazuteru; Masutani, Motomaru; Yoon, Jung Han; Park, Hun Sik; Chae, In-Ho; Kim, Moo Hyun; Jeong, Myung Ho; Rha, Seungwoon; Kim, Chongjin; Kim, Hyo-Soo; Hong, Taekjong; Tahk, Seung-Jea; Kim, Youngkwon; Busmane, Arija; Pontaga, Natalija; Strelnieks, Aldis; Mintale, Iveta; Sime, Iveta; Petrulioniene, Zaneta; Kavaliauskiene, Roma; Jurgaitiene, Ruta; Sakalyte, Gintare; Slapikas, Rimvydas; Norkiene, Sigute; Misonis, Nerijus; Kibarskis, Aleksandras; Kubilius, Raimondas; Bojovski, Stojko; Lozance, Nensi; Kjovkaroski, Aleksandar; Doncovska, Snezana; Ong, Tiong Kiam; Kasim, Sazzli; Maskon, Oteh; Kandasamy, Balachandran; Liew, Houng B.; Mohamed, Wan Mohd Izani Wan; Garcia Castillo, Armando; Carrillo Calvillo, Jorge; Fajardo Campos, Pedro; Nunez Fragoso, Juan Carlos; Bayram Llamas, Edmundo Alfredo; Alcocer Gamba, Marco Antonio; Carranza Madrigal, Jaime; Gonzalez Salas, Luis Gerardo; Lopez Rosas, Enrique; Gonzalez Diaz, Belinda; Salcido Vazquez, Eduardo; Nacoud Ackar, Alfredo; Llamas Esperon, Guillermo Antonio; Martinez Sanchez, Carlos Rodolfo; Guerrero De Leon, Maria; Suarez Otero, Rodrigo; Fanghanel Salmon, Guillermo; Perez Rios, Jesus Antonio; Garza Ruiz, Jose Angel; Breedveld, Robert W.; Hoogslag, Pieter A.M.; Suryapranata, Harry; Oomen, Antonius; Wiersma, Jacobijne J.; Van Der Wal, Ruud M.A.; Van Huysduynen-Monraats, Pascalle S. Hooft; Karalis, Ioannis; Verdel, Gerardus J.E.; Brueren, Bart R.G.; Troquay, Roland P.Th; Viergever, Eric P.; Al-Windy, Nadea Y.Y.; Bartels, Gerard L.; Cornel, Jan H.; Hermans, Walter R.M.; Herrman, Johannes P.R.; Bos, Robert J.; Groutars, Reginald G.EJ.; Van Der Zwaan, Coenraad C.; Kaplan, Refik; Ronner, Eelko; Groenemeijer, Bjorn E.; Bronzwaer, Patrick N.A.; Liem, Anho A.H.; Rensing, Bernard J.WM.; Bokern, Marcel J.JA.; Nijmeijer, Remco; Hersbach, Ferry M.RJ.; Willems, Frank F.; Gosselink, Antonius T.M.; Elliott, John; Wilkins, Gerard; Fisher, Raewyn; Scott, Douglas; Hart, Hamish; Stewart, Ralph; Harding, Scott; Ternouth, Ian; Fisher, Nicholas; Aitken, Denise; Anscombe, Russell; Davidson, Laura; Tomala, Tadeusz; Nygard, Ottar; Sparby, Jon Arne; Andersen, Kjell; Gullestad, Lars; Jortveit, Jarle; Munk, Peter S.; Singsaas, Erlend Gyllensten; Hurtig, Ulf; Calderon Ticona, Jorge R.; Durand Velasquez, Julio R.; Negron Miguel, Sandra A.; Sanabria Perez, Enrique S.; Carrion Chambilla, Jesus M.; Chavez Ayala, Carlos A.; Castillo Leon, Reynaldo P.; Vargas Gonzales, Rolando J.; Hernandez Zuniga, Jose D.; Camacho Cosavalente, Luis A.; Bravo Mannucci, Jorge E.; Heredia Landeo, Javier; Llerena Navarro, Nassip C.; Roldan Concha, Yudy M.; Rodriguez Chavez, V-ctor E.; Anchante Hernandez, Henry A.; Zea Nunez, Carlos A.; Mogrovejo Ramos, Walter; Ferrolino, Arthur; Sy, Rosa Allyn G.; Tirador, Louie; Matiga, Generoso; Coching, Raul Martin; Bernan, Alisa; Rogelio, Gregorio; Morales, Dante D.; Tan, Edgar; Sulit, Dennis Jose; Wlodarczak, Adrian; Jaworska, Krystyna; Skonieczny, Grzegorz; Pawlowicz, Lidia; Wojewod, Pawel; Busz-Papiez, Benita; Bednarski, Janusz; Goch, Aleksander; Staneta, Pawel; Dulak, Elzbieta; Saminsk, Krzysztof; Krasowski, Wlodzimierz; Sudnik, Wanda; Zurakowski, Aleksander; Skorski, Marcin; Lysek, Roman; Miklaszewicz, Beata; Kubica, Jacek; Lipko, Jan Andrzej; Kostarska-Srokosz, Edyta; Piepiorka, Marek; Drzewiecka, Anna; Sciborski, Ryszard; Stasiewski, Arkadiusz; Blicharski, Tomasz; Bystryk, Leszek; Szpajer, Michal; Korol, Marek; Czerski, Tomasz; Mirek-Bryniarska, Ewa; Gniot, Jacek; Lubinski, Andrzej; Gorny, Jerzy; Franek, Edward; Raczak, Grzegorz; Szwed, Hanna; Monteiro, Pedro; Bastos, Jose Mesquita; Pereira, Helder H.; Martins, Dinis; Seixo, Filipe; Mendonca, Carlos; Botelho, Ana; Minescu, Bogdan; Istratoaie, Octavian; Tesloianu, Dan N.; Cristian, Gabriel; Podoleanu, Cristian G.C.; Constantinescu, Mircea C.A.; Bengus, Cristina M.; Militaru, Constantin; Rosu, Doina; Parepa, Irinel R.; Matei, Adrian V.; Alexandru, Tom M.; Coman, Ioan; Cioranu, Rodica Stanescu; Dimulescu, Doina; Shvarts, Yury; Orlikova, Olga; Kobalava, Zhanna; Barbarash, Olga L.; Markov, Valentin; Lyamina, Nadezhda; Gordienko, Alexander; Zrazhevsky, Konstantin; Vishnevsky, Alexander Y.; Gurevich, Victor; Stryuk, Raisa; Lomakin, Nikita V.; Bokarev, Igor; Shalaev, Sergey; Khaisheva, Larisa; Chizhov, Petr; Viktorova, Inna; Osokina, Natalya; Akatova, Evgenia; Chumakova, Galina; Libov, Igor; Voevoda, Mikhail I.; Tretyakova, Tatyana V.; Baranov, Evgeny; Shustov, Sergey; Yakushin, Sergey; Gordeev, Ivan; Khasanov, Niiaz; Reshetko, Olga; Sotnikova, Tatiana; Molchanova, Olga; Nikolaev, Konstantin; Gapon, Liudmila; Baranova, Elena; Shogenov, Zaur; Kosmachova, Elena; Karpov, Yuriy; Povzun, Anton; Egorova, Liudmila; Tyrenko, Vadim V.; Ivanov, Igor G.; Kanorsky, Sergey; Simic, Dragan; Ivanovic, Nikola; Davidovic, Goran; Tasic, Nebojsa; Asanin, Milika R.; Stojic, Stevo; Apostolovic, Svetlana R.; Ilic, Stevan; Putnikovic, Biljana; Stankovic, Aleksandar; Arandjelovic, Aleksandra; Radovanovic, Slavica; Balinovac, Jovan; Dincic, Dragan V.; Seferovic, Petar; Dodic, Slobodan; Dimkovic, Sinisa; Poh, Kian-Keong; Ong, Hean Yee; Micko, Karol; Nociar, Jan; Pella, Daniel; Fulop, Peter; Hranai, Marian; Palka, Juraj; Mazur, Juraj; Majercak, Ivan; Dzupina, Andrej; Fazekas, Frantisek; Gonsorcik, Jozef; Bugan, Viliam; Selecky, Juraj; Kamensky, Gabriel; Strbova, Jaroslava; Smik, Rudolf; Dukat, Andrej; Olexa, Peter; Zuran, Ivan; Poklukar, Janez; Suligoj, Natasa Cerni; Cevc, Matija; Cyster, Henry P.; Ranjith, Naresh; Corbett, Clive; Bayat, Junaid; Makotoko, Ellen Makoali; Kapp, Ilse E.; Basson, Matthys M. de V.; Lottering, Hanlie; Van Zyl, Louis J.; Sebastian, Peter J.; Pillay, Thayabran; Saaiman, Jan A.; Commerford, Patrick J.; Cassimjee, Soraya; Ebrahim, Iftikhar O.; Sarvan, Mahomed; Mynhardt, Joseph H.; Reuter, Helmuth; Moodley, Rajendran; Vida, Manuel; Cequier Fillat, Angel R.; Peris, Vicente Bodi; Jimenez, Francisco Fuentes; Marin, Francisco; Cruz Fernandez, Jose M.; Gil-Extremera, Blas; Diz, Fernando Worner; Garcia-Dorado, David; Iniguez, Andres; Tunon Fernandez, Jose; Gonzalez-Juanatey, Jose R.; Fernandez Portales, Javier; Civeira Murillo, Fernando; Matas Pericas, Laia; Luis Zamorano, Jose; De Mora Martin, Manuel; Bruguera Cortada, Jordi; Alonso Martin, Joaquin J.; De Berrazueta Fernandez, Jose R.; Diaz Fernandez, Jose Francisco; Garcia Lledo, Jose Alberto; Cosin Sales, Juan; Botas Rodriguez, Javier; Gusi Tragant, Gabriel; Benedicto, Amparo; Gonzalez-Juanatey, Carlos; Camprubi Potau, Mercedes; Plaza Perez, Ignacio; Moris De La Tassa, Cesar; Loma-Osorio Rincon, Pablo; Balaguer Recena, Javier; Escudier, Juan M.; Coca Payeras, Antonio; Alonso Orcajo, Norberto; Valdivielso, Pedro; Constantine, Godwin; Haniffa, Ruvaiz; Tissera, Nirmali; Amarasekera, Stanley; Fernando, Nimali; Jayawardena, Jayanthimala; Santharaj, Wijeyasingam; Ekanayaka, Ruvan; Mendis, Sepalika; Senaratne, Vajira; Mayurathan, Gnanamoorthy; Sirisena, Thilak; Rajapaksha, Ajantha; Herath, Jagath I.; Amarasena, Naomali; Berglund, Stefan; Rasmanis, Gundars; Witt, Nils; Mourtzinis, Georgios; Nicol, Peter; Hansen, Ole; Romeo, Stefano; Jensen, Steen Agergaard; Torstensson, Ingemar; Ahremark, Ulf; Sundelin, Torbjorn; Moccetti, Tiziano; Mach, Francois; Binder, Ronald; Tsai, Wei-Chuan; Ueng, Kwo-Chang; Lai, Wen-Ter; Liu, Ming-En; Hwang, Juey-Jen; Yin, Wei-Hsian; Hsieh, I-Chang; Lin, Wei Hsiang; Kuo, Jen-Yuan; Huang, Tsuei-Yuan; Fang, Chih-Yuan; Kaewsuwanna, Pinij; 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Source: ISSN:0735-1097 ; ISSN:1558-3597 ; Journal Of The American College Of Cardiology, vol. 73 (4), (387-396.
Publisher Information: Elsevier
Publication Year: 2019
Subject Terms: Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; acute coronary syndrome; alirocumab; total events; ACUTE CORONARY SYNDROMES; STATIN THERAPY; REDUCTION; Aged; Antibodies; Monoclonal; Humanized; Drug Therapy; Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; ODYSSEY OUTCOMES Committees and Investigators; 1102 Cardiorespiratory Medicine and Haematology; 1117 Public Health and Health Services; Cardiovascular System & Hematology; 3201 Cardiovascular medicine and haematology
Description: BACKGROUND: The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths. OBJECTIVES: This pre-specified analysis determined the extent to which alirocumab reduced total (first and subsequent) nonfatal cardiovascular events and all-cause deaths in ODYSSEY OUTCOMES. METHODS: Hazard functions for total nonfatal cardiovascular events (myocardial infarction, stroke, ischemia-driven coronary revascularization, and hospitalization for unstable angina or heart failure) and death were jointly estimated, linked by a shared frailty accounting for patient risk heterogeneity and correlated within-patient nonfatal events. An association parameter also quantified the strength of the linkage between risk of nonfatal events and death. The model provides accurate relative estimates of nonfatal event risk if nonfatal events are associated with increased risk for death. RESULTS: With 3,064 first and 5,425 total events, 190 fewer first and 385 fewer total nonfatal cardiovascular events or deaths were observed with alirocumab compared with placebo. Alirocumab reduced total nonfatal cardiovascular events (hazard ratio: 0.87; 95% confidence interval: 0.82 to 0.93) and death (hazard ratio: 0.83; 95% confidence interval: 0.71 to 0.97) in the presence of a strong association between nonfatal and fatal event risk. CONCLUSIONS: In patients with ACS, the total number of nonfatal cardiovascular events and deaths prevented with alirocumab was twice the number of first events prevented. Consequently, total event reduction is a more comprehensive metric to capture the totality of alirocumab clinical efficacy after ACS. ; sponsorship: This study was supported by Sanofi, Regeneron Pharmaceuticals, Inc., and ...
Document Type: article in journal/newspaper
File Description: application/pdf
Language: English
Relation: https://lirias.kuleuven.be/handle/20.500.12942/701532; https://doi.org/10.1016/j.jacc.2018.10.039; https://pubmed.ncbi.nlm.nih.gov/30428396
DOI: 10.1016/j.jacc.2018.10.039
Availability: https://lirias.kuleuven.be/handle/20.500.12942/701532; https://hdl.handle.net/20.500.12942/701532; https://lirias.kuleuven.be/retrieve/a48002f3-6373-463e-a91c-c630334dd792; https://doi.org/10.1016/j.jacc.2018.10.039; https://pubmed.ncbi.nlm.nih.gov/30428396
Rights: info:eu-repo/semantics/openAccess ; public ; https://creativecommons.org/licenses/by-nc-nd/4.0/
Accession Number: edsbas.64357D45
Database: BASE