| Title: |
Relationship Between Dietary Phosphate Intake and Biomarkers of Bone and Mineral Metabolism in Australian Adults With Chronic Kidney Disease |
| Authors: |
Conley, M; Campbell, KL; Hawley, CM; Lioufas, NM; Elder, GJ; Badve, SV; Pedagogos, E; Milanzi, E; Pascoe, EM; Valks, A; Toussaint, ND |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2021 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Clinical sciences; Nephrology and urology; Nutrition and dietetics |
| Description: |
Objective: Higher serum phosphate is associated with increased adverse outcomes including cardiovascular disease. Abnormalities of bone and mineral metabolism in chronic kidney disease (CKD), including higher serum phosphate, are important risk factors for increased cardiovascular disease. Associations between dietary phosphate intake and biochemical and cardiovascular parameters in non-dialysis CKD patients, however, have not been adequately studied. This study aimed to explore associations between phosphate intake and biomarkers of bone and mineral metabolism and intermediate cardiovascular markers in adults with stage 3-4 CKD. Design and Methods: One hundred thirty-two participants enrolled in the IMpact of Phosphate Reduction On Vascular End-points in Chronic Kidney Disease trial were invited to participate in this sub-study. At baseline, dietary phosphate intake and its source (animal, plant, or a mixture of animal and plant) were determined using a 7-day self-administered diet food record, and measurements were made of serum and urinary phosphate, serum calcium, parathyroid hormone, fibroblast growth factor-23, and the intermediate cardiovascular markers pulse wave velocity (PWV) and abdominal aortic calcification. The relationships between dietary phosphate intake and these bone metabolism and cardiovascular markers were explored using Pearson's correlation and linear regression. The effect of source of phosphate intake was analyzed using compositional data analysis. Results: Ninety participants (age 64 ± 12 years, 68% male, estimated glomerular filtration rate 26.6 ± 7.6 mL/min/1.73 m2, daily phosphate intake 1,544 ± 347 mg) completed the study. Correlations among dietary phosphate intake and biochemical measures, PWV, and abdominal aortic calcification ranged from r = −0.13 to r = +0.13. Linear regression showed no association between dietary phosphate measurements and biochemical or cardiovascular parameters. Source of phosphate intake was associated with PWV (P = .01), but not with other biomarkers of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of Renal Nutrition; Conley, M; Campbell, KL; Hawley, CM; Lioufas, NM; Elder, GJ; Badve, SV; Pedagogos, E; Milanzi, E; Pascoe, EM; Valks, A; Toussaint, ND, Relationship Between Dietary Phosphate Intake and Biomarkers of Bone and Mineral Metabolism in Australian Adults With Chronic Kidney Disease, Journal of Renal Nutrition, 2021; https://hdl.handle.net/10072/408978 |
| DOI: |
10.1053/j.jrn.2021.07.004 |
| Availability: |
https://hdl.handle.net/10072/408978; https://doi.org/10.1053/j.jrn.2021.07.004 |
| Rights: |
open access |
| Accession Number: |
edsbas.6448A4AF |
| Database: |
BASE |