| Title: |
High Risk of Cognitive and Functional Decline after Postoperative Delirium |
| Authors: |
Bickel, Horst; Gradinger, Reiner; Kochs, Eberhard; Förstl, Hans |
| Publisher Information: |
S. Karger AG |
| Publication Year: |
2008 |
| Collection: |
Munich University of Technology (TUM): mediaTUM |
| Subject Terms: |
info:eu-repo/classification/ddc; Delirium; prognosis; Confusional state; Cognitive decline; prediction; Disability |
| Description: |
Background/Aims: The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. Methods: Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status during hospital stay. Outcome variables were determined at an average of 8 and 38 months after discharge from hospital. Results: Fourty-one patients developed postoperative delirium. Delirium was a strong independent predictor of cognitive impairment and the occurrence of severe dependency in activities of daily living. The associations were more marked for the long- than for the short-term outcome. Thirty-eight months after discharge from hospital, 53.8% of the surviving patients with postoperative delirium suffered from cognitive impairment, as compared to only 4.4% of the nondelirious participants. Logistic regression analysis adjusted for age, sex, medical comorbidity and preoperative cognitive performance revealed highly significant associations between delirium and cognitive impairment (OR = 41.2; 95% CI = 4.3–396.2), subjective memory decline (OR = 6.2; 95% CI = 1.5–25.8) and incident need for long-term care (OR = 5.6; 95% CI = 1.6–19.7). Conclusion: The present study confirms a poor prognosis after delirium in elderly patients. The findings suggest that delirium does not simply persist for a certain time but also predicts a future cognitive decline with an increased risk of dementia. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://mediatum.ub.tum.de/1218725; https://mediatum.ub.tum.de/doc/1218725/document.pdf |
| DOI: |
10.1159/000140804 |
| Availability: |
https://mediatum.ub.tum.de/1218725; https://mediatum.ub.tum.de/doc/1218725/document.pdf; https://doi.org/10.1159/000140804 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.6452D860 |
| Database: |
BASE |