| Title: |
Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma |
| Authors: |
Webb, E Kate; Ely, Timothy D; Rowland, Grace E; Lebois, Lauren A M; van Rooij, Sanne J H; Bruce, Steven E; Jovanovic, Tanja; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Swor, Robert A; Pascual, Jose L; Seamon, Mark J; Datner, Elizabeth M; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; Sergot, Paulina; Sanchez, Leon D; Kessler, Ronald C; Koenen, Karestan C; McLean, Samuel A; Stevens, Jennifer S; Ressler, Kerry J; Harnett, Nathaniel G |
| Contributors: |
Emergency Medicine |
| Source: |
JAMA network open ; 6 ; 9 ; e2334483 ; United States |
| Publication Year: |
2023 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Description: |
Importance: Differences in neighborhood socioeconomic characteristics are important considerations in understanding differences in risk vs resilience in mental health. Neighborhood disadvantage is associated with alterations in the function and structure of threat neurocircuitry. Objective: To investigate associations of neighborhood disadvantage with white and gray matter and neural reactivity to positive and negative stimuli in the context of trauma exposure. Design, setting, and participants: In this cross-sectional study, survivors of trauma who completed sociodemographic and posttraumatic symptom assessments and neuroimaging were recruited as part of the Advancing Understanding of Recovery After Trauma (AURORA) study between September 2017 and June 2021. Data analysis was performed from October 25, 2022, to February 15, 2023. Exposure: Neighborhood disadvantage was measured with the Area Deprivation Index (ADI) for each participant home address. Main outcomes and measures: Participants completed separate threat and reward tasks during functional magnetic resonance imaging. Diffusion-weighted and high-resolution structural images were also collected. Linear models assessed the association of ADI with reactivity, microstructure, and macrostructure of a priori regions of interest after adjusting for income, lifetime trauma, sex at birth, and age. A moderated-mediation model tested whether ADI was associated with neural activity via microstructural changes and if this was modulated by PTSD symptoms. Results: A total of 280 participants (183 females [65.4%]; mean [SD] age, 35.39 [13.29] years) completed the threat task and 244 participants (156 females [63.9%]; mean [SD] age, 35.10 [13.26] years) completed the reward task. Higher ADI (per 1-unit increase) was associated with greater insula (t274 = 3.20; β = 0.20; corrected P = .008) and anterior cingulate cortex (ACC; t274 = 2.56; β = 0.16; corrected P = .04) threat-related activity after considering covariates, but ADI was not associated with reward reactivity. ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
JAMA Network Open; https://doi.org/10.1001/jamanetworkopen.2023.34483; Webb EK, Ely TD, Rowland GE, Lebois LAM, van Rooij SJH, Bruce SE, Jovanovic T, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Kessler RC, Koenen KC, McLean SA, Stevens JS, Ressler KJ, Harnett NG. Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma. JAMA Netw Open. 2023 Sep 5;6(9):e2334483. doi:10.1001/jamanetworkopen.2023.34483. PMID: 37721751; PMCID: PMC10507487.; http://hdl.handle.net/20.500.14038/52656 |
| DOI: |
10.1001/jamanetworkopen.2023.34483 |
| Availability: |
https://doi.org/10.1001/jamanetworkopen.2023.34483; https://hdl.handle.net/20.500.14038/52656 |
| Rights: |
Copyright 2023 Webb EK et al. JAMA Network Open. This is an open access article distributed under the terms of the CC-BY License. |
| Accession Number: |
edsbas.64B5AC46 |
| Database: |
BASE |