| Title: |
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation:Findings from the pregnancy and childhood epigenetics (PACE) consortium |
| Authors: |
Sharp,Gemma C.; Salas,Lucas A.; Monnereau,Claire; Allard,Catherine; Yousefi,Paul; Everson,Todd M.; Bohlin,Jon; Xu,Zongli; Huang,Rae Chi; Reese,Sarah E.; Xu,Cheng-Jian; Baïz,Nour; Hoyo,Cathrine; Agha,Golareh; Roy,Ritu; Holloway,John W.; Ghantous,Akram; Merid,Simon K.; Bakulski,Kelly M.; Küpers,Leanne K.; Zhang,Hongmei; Richmond,Rebecca C.; Page,Christian M.; Duijts,Liesbeth; Lie,Rolv T.; Melton,Phillip E.; Vonk,Judith M.; Nohr,Ellen A.; Williams-DeVane,Clar Lynda; Huen,Karen; Rifas-Shiman,Sheryl L.; Ruiz-Arenas,Carlos; Gonseth,Semira; Rezwan,Faisal I.; Herceg,Zdenko; Ekström,Sandra; Croen,Lisa; Falahi,Fahimeh; Perron,Patrice; Karagas,Margaret R; Quraishi,Bilal M.; Suderman,Matthew J.; Magnus,Maria C.; Jaddoe,Vincent W V; Taylor,Jack A; Anderson,Denise; Zhao,Shanshan; Smit, Henriette A.; Josey,Michele J.; Bradman,Asa; Baccarelli,Andrea A.; Bustamante,Mariona; Håberg,Siri E.; Pershagen,Göran; Hertz-Picciotto,Irva; Newschaffer,Craig; Corpeleijn,Eva; Bouchard,Luigi; Lawlor,Debbie A.; Maguire,Rachel L.; Barcellos,Lisa F.; Smith,George Davey; Eskenazi,Brenda; Karmaus,Wilfried; Marsit,Carmen J.; Hivert,Marie-France; Snieder,Harold; Fallin,M. Daniele; Melén,Erik; Munthe-Kaas,Monica C.; Arshad,S Hasan; Wiemels,Joseph L.; Annesi-Maesano,Isabella; Vrijheid,Martine; Oken,Emily; Holland,Nina; Murphy,Susan K.; Sørensen,Thorkild I A; Koppelman,Gerard H; Newnham,John P; Wilcox,Allen J.; Nystad,Wenche; London,Stephanie J.; Felix,Janine F.; Relton,Caroline L; UMC Utrecht; Public Health Epidemiologie; Circulatory Health; Child Health; JC onderzoeksprogramma Cardiovascular Health |
| Publication Year: |
2017 |
| Subject Terms: |
Molecular Biology; Genetics; Genetics(clinical); Journal Article |
| Description: |
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0964-6906 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/357145 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/357145 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.64BFB0AF |
| Database: |
BASE |