| Title: |
Population genomics of Anopheles darlingi , the principal South American malaria vector mosquito |
| Authors: |
Tennessen, Jacob; Brosula, Raphael; Chabanol, Estelle; Bickersmith, Sara; Early, Angela; Laws, Margaret; Kelley, Katrina; Grillet, Maria Eugenia; Gamboa, Dionicia; Lucas, Eric; Duchemin, Jean-Bernard; Quiñones, Martha; Mureb Sallum, Maria Anice; Bergo, Eduardo; Moreno, Jorge; Nagi, Sanjay; Arisco, Nicholas; Sooklall, Mohini; Niles-Robin, Reza; Castro, Marcia; Cox, Horace; Gendrin, Mathilde; Conn, Jan; Neafsey, Daniel |
| Contributors: |
Harvard T.H. Chan School of Public Health; Broad Institute Cambridge; Harvard University-Massachusetts Institute of Technology (MIT); Institut Pasteur de la Guyane; Pasteur Network (Réseau International des Instituts Pasteur); Wadsworth Center; New York State Department of Health Albany; Universidad Central de Venezuela (UCV); Universidad Peruana Cayetano Heredia - Peruvian University Cayetano Heredia Lima, Peru (UPCH); Liverpool School of Tropical Medicine (LSTM); Universidad Nacional de Colombia Bogotà (UNAL); Universidade de São Paulo = University of São Paulo (USP); Institut Pasteur de São Paulo; Instituto de Altos Estudios en Salud Dr. Arnoldo Gabaldón; Ministry of Public Health Georgetown, Guyana; State University of New York (SUNY); National Institutes of Health grant U19AI110818 (DEN)20National Institutes of Health grant R01AI110112 (JEC, DEN)Bill & Melinda Gates Foundation grant INV-009416 (DEN)Agence Nationale de la Recherche grant ANR-18-CE15-0007 (MG)National Council for Scientific and Technological Development (CNPq) grant303382/2022-8 (MAMS); ANR-18-CE15-0007,MosMi,Remodelage du microbiote de moustique pour étudier son impact sur la transmission du paludisme(2018) |
| Source: |
https://hal.science/hal-05124021 ; 2025. |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Collection: |
Réseau International des Instituts Pasteur, Paris: HAL-RIIP |
| Subject Terms: |
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
| Description: |
Malaria in South America remains a serious public health problem. Anopheles ( Nyssorhynchus ) darlingi is the most important malaria vector across tropical Latin America. Vector-targeted disease control efforts require a thorough understanding of mosquito demographic and evolutionary patterns. We present and analyze whole genomes of 1094 A. darlingi (median depth 18x) from six South American countries. We observe deep geographic population structure, high genetic diversity including thirteen putative segregating inversions, and no evidence for cryptic sympatric taxa despite high interpopulation divergence. Strong signals of selection are plausibly driven by insecticides, especially on cytochrome P450 genes, one of which we validated experimentally. Our results will facilitate effective mosquito surveillance and control, while highlighting ongoing challenges that a diverse vector poses for malaria elimination in the western hemisphere. |
| Document Type: |
report |
| Language: |
English |
| Relation: |
BIORXIV: 2025.03.13.643102 |
| DOI: |
10.1101/2025.03.13.643102 |
| Availability: |
https://hal.science/hal-05124021; https://hal.science/hal-05124021v1/document; https://hal.science/hal-05124021v1/file/Tennessen_et_al-2025-bioRxiv.pdf; https://doi.org/10.1101/2025.03.13.643102 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.64F5F0C7 |
| Database: |
BASE |