| Title: |
Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI:Results of the ISACS-STEMI COVID-19 Registry |
| Authors: |
De Luca,Giuseppe; Manzo-Silberman,Stephane; Algowhary,Magdy; Uguz,Berat; Oliveira,Dinaldo C.; Ganyukov,Vladimir; Busljetik,Oliver; Cercek,Miha; Okkels,Lisette; Loh,Poay Huan; Calmac,Lucian; Ferrer,Gerard Roura i.; Quadros,Alexandre; Milewski,Marek; Scotto di Uccio,Fortunato; von Birgelen,Clemens; Versaci,Francesco; Ten Berg,Jurrien; Casella,Gianni; Wong Sung Lung,Aaron; Kala,Petr; Díez Gil,José Luis; Carrillo,Xavier; Dirksen,Maurits; Becerra,Victor; Lee,Michael Kang yin; Juzar,Dafsah Arifa; de Moura Joaquim,Rodrigo; Paladino,Roberto; Milicic,Davor; Davlouros,Periklis; Bakraceski,Nikola; Zilio,Filippo; Donazzan,Luca; Kraaijeveld, Adriaan; Galasso,Gennaro; Arpad,Lux; Marinucci,Lucia; Guiducci,Vincenzo; Menichelli,Maurizio; Scoccia,Alessandra; Yamac,Aylin Hatice; Ugur Mert,Kadir; Flores Rios,Xacobe; Kovarnik,Tomas; Kidawa,Michal; Moreu,Josè; Flavien,Vincent; Fabris,Enrico; Martínez-Luengas,Iñigo Lozano; Boccalatte,Marco; Ojeda,Francisco Bosa; Arellano-Serrano,Carlos; Caiazzo,Gianluca; Cirrincione,Giuseppe; Kao,Hsien Li; Forés,Juan Sanchis; Vignali,Luigi; Pereira,Helder; Ordoñez,Santiago; Arat Özkan,Alev; Scheller,Bruno; Lehtola,Heidi; Teles,Rui; Mantis,Christos; Antti,Ylitalo; Brum Silveira,João António; Zoni,Cesar Rodrigo; Bessonov,Ivan; Uccello,Giuseppe; Kochiadakis,George; Alexopulos,Dimitrios; Uribe,Carlos E.; Kanakakis,John; Faurie,Benjamin; Gabrielli,Gabriele; Barrios,Alejandro Gutierrez; Bachini,Juan Pablo; Rocha,Alex; Tam,Frankie C.C.; Rodriguez,Alfredo; Lukito,Antonia Anna; Saint-Joy,Veauthyelau; Pessah,Gustavo; Tuccillo,Andrea; Ielasi,Alfonso; Cortese,Giuliana; Parodi,Guido; Bouraghda,Mohamed Abed; Moura,Marcia; Kedhi,Elvin; Lamelas,Pablo; Suryapranata,Harry; Nardin,Matteo; Verdoia,Monica; Team Medisch; Circulatory Health |
| Publication Year: |
2023 |
| Subject Terms: |
COVID-19; gender; percutaneous coronary intervention; ST-segment elevation myocardial infarction; General Medicine |
| Description: |
BACKGROUND: Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. METHODS: This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March-June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. RESULTS: We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825-0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31-2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96-1.34], p = 0.12). CONCLUSIONS: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
2077-0383 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/448548 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/448548 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.65016D90 |
| Database: |
BASE |