| Description: |
Rong Chen,1– 3,* Shu-Ting Hong,1,2,* Shi-Ying Wu,3 Xiao-Qi Jiang,3 Xue-Jiao Su,3 Ying-Qi Zhang,3 Zhen Mei,1,2 Han Lin,1,2 Heng Lin,1,2 Xue-Qun Hu,1,2 Yuan-Xiang Lin,1,2,4 Feng Wang1,2,4 1Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 4Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Wang, Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, Tel +8615005018772, Email 15005018772@163.com Yuan-Xiang Lin, Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, +8613906918894, Email lyx99070@163.comPurpose: This study aimed to further explore the association between histopathology of the epileptogenic zone and postsurgical seizure outcome in epilepsy patients, with a specific focus on dual or multiple pathologies.Patients and Methods: In this single-center retrospective cohort study, 449 patients who underwent epilepsy surgery between 2017 and 2024 at The First Affiliated Hospital of Fujian Medical University were included. Clinical data were collected, including histopathological diagnoses and seizure outcome at ≥ 12 months postoperatively. We investigated the association of histopathology, epilepsy duration, the number of preoperative antiseizure medications (ASMs), and MRI findings with ... |