| Title: |
Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer |
| Authors: |
Bernstein, A.J.; Keeman, R.; Hurson, A.N.; Blows, F.M.; Bolla, M.K.; Miller, J.L.; Milne, R.L.; Horlings, H.; van den Broek, A.J.; Bodelon, C.; Hodge, J.M.; Patel, A.V.; Teras, L.R.; Canzian, F.; Kaaks, R.; Brenner, H.; Schöttker, B.; Behrens, S.; Chang-Claude, J.; Maurer, T.; Obi, N.; Couch, F.J.; Ali, H.R.; Caldas, C.; Andrulis, I.; Glendon, G.; Mulligan, A.M.; Mesker, W.; Jager, A.; Heemskerk-Gerritsen, A.; Devilee, P.; Lawrence, S.M.; Lissowska, J.; Mutreja, K.; Ahearn, T.; Chanock, S.; Duggan, M.A.; Eccles, D.; Jones, J.L.; Tapper, W.; Hollestelle, A.; Hooning, M.; Martens, J.; van Deurzen, C.H.M.; Cox, A.; Cross, S.S.; Hartman, M.; Li, J.; Putti, T.C.; Hamann, U.; Rashid, M.; Jakubowska, A.; Camp, N.; Cessna, M.H.; Berrington de Gonzalez, A.; Bialkowska, K.; Gronwald, J.; Lubiński, J.; Yadav, S.; Lio, P.; Easton, D.F.; Abubakar, M.; Garcia-Closas, M.; Pharoah, P.D.P.; Schmidt, M.K. |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2026 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Breast cancer immune response is important to patient outcome, but the prognostic interaction between tissue-infiltrating immune cell (TIIC) types is not well-characterized. We evaluated the associations between CD8 + , FOXP3+, CD20 + , and CD163 + TIICs and breast cancer-specific survival (BCSS). We developed an AI in Halo to score TIIC percentage by compartment (overall, stromal, or intra-tumoral) in 99,051 microarray images from 12,285 female breast cancers. The associations between log-transformed TIIC scores and BCSS were assessed using Cox regression. CD8 + and FOXP3+ TIICs were associated with better BCSS in ER-negative disease; CD8 + and CD20 + TIICs were associated with a better prognosis in ER-positive disease; and CD163 + TIICs were associated with a poorer prognosis in ER-positive disease in multi-marker models. These results may have implications for breast cancer immunotherapy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/238829/1/Compartment-specific%20tumor-infiltrating%20immune%20cells%20and%20prognosis%20in%20breast%20cancer.pdf; Bernstein, A.J., Keeman, R., Hurson, A.N. et al. (62 more authors) (2026) Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer. iScience, 29 (2). 114759. ISSN: 2589-0042 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/238829/ |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.651B39E3 |
| Database: |
BASE |