| Title: |
Immune-Based Therapies and the Role of Microsatellite Instability in Pancreatic Cancer |
| Authors: |
Michele Ghidini; Andrea Lampis; Milko B. Mirchev; Ali Fuat Okuducu; Margherita Ratti; Nicola Valeri; Jens C. Hahne |
| Source: |
Genes ; Volume 12 ; Issue 1 ; Pages: 33 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2020 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
pancreatic cancer; microsatellite instability; Lynch syndrome; mismatch repair system; immune-based therapy |
| Description: |
Pancreatic cancer is one of the most aggressive malignancies with limited treatment options thus resulting in high morbidity and mortality. Among all cancers, with a five-year survival rates of only 2–9%, pancreatic cancer holds the worst prognostic outcome for patients. To improve the overall survival, an earlier diagnosis and stratification of cancer patients for personalized treatment options are urgent needs. A minority of pancreatic cancers belong to the spectrum of Lynch syndrome-associated cancers and are characterized by microsatellite instability (MSI). MSI is a consequence of defective mismatch repair protein functions and it has been well characterized in other gastrointestinal tumors such as colorectal and gastric cancer. In the latter, high levels of MSI are linked to a better prognosis and to an increased benefit to immune-based therapies. Therefore, the same therapies could offer an opportunity of treatment for pancreatic cancer patients with MSI. In this review, we summarize the current knowledge about immune-based therapies and MSI in pancreatic cancer. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular Genetics and Genomics; https://dx.doi.org/10.3390/genes12010033 |
| DOI: |
10.3390/genes12010033 |
| Availability: |
https://doi.org/10.3390/genes12010033 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.65430F89 |
| Database: |
BASE |