| Title: |
Structural brain changes in post-COVID condition and its relationship with cognitive impairment |
| Authors: |
Pacheco Jaime, Laura; Garcia Vicente, Carla; Ariza González, Mar; Cano, Neus; Garolera i Freixa, Maite; Carreras Vidal, Lourdes; Roura, Ignacio; Capdevila Lacasa, Clara; Oltra González, Javier; Pardo, Jèssica; Martín Barceló, Cristina; Campabadal Delgado, Anna; Sala Llonch, Roser; Bargalló Alabart, Núria; Barrué, Cristian; Bejar, Javier; Cortés, Claudio Ulises; Junqué i Plaja, Carme, 1955-; Segura i Fàbregas, Bàrbara; NAUTILUS-Project Collaborative Group |
| Source: |
Articles publicats en revistes (Biomedicina) |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2025 |
| Collection: |
Dipòsit Digital de la Universitat de Barcelona |
| Subject Terms: |
COVID-19; Trastorns de la cognició; Imatges per ressonància magnètica; Cognition disorders; Magnetic resonance imaging |
| Description: |
It has been estimated that ∼4% of individuals infected with SARS-CoV-2 will be diagnosed with post-COVID condition. Previous studies have evidenced the presence of cognitive dysfunction and structural brain changes in infected individuals; however, the relationship between structural changes and cognitive alterations in post-COVID condition is still not clear. Consequently, the aim of this work is to study structural brain alterations in post-COVID condition patients after almost 2 years of infection and their likely relationship with patients' cognitive impairment. Additionally, the association with blood biomarkers and clinical variables was also explored. One hundred and twenty-eight individuals with post-COVID condition and 37 non-infected healthy controls from the Nautilus Project (ClinicalTrials.gov IDs: NCT05307549 and NCT05307575) underwent structural brain magnetic resonance imaging and a comprehensive neuropsychological assessment. A subsample of 66 post-COVID participants also underwent blood extraction to obtain levels of blood biomarkers. Cortical thickness and subcortical volumes were obtained and analysed using FreeSurfer (v7.1). FMRIB Software Library software (v6.0.4) was used to perform grey matter voxel-based analysis and to study microstructural white matter integrity. Patients with post-COVID performed significantly worse in working and verbal memory, processing speed, verbal fluency and executive functions, compared to healthy controls. Moreover, patients with post-COVID showed increased cortical thickness in the right superior frontal and the right rostral middle frontal gyri that negatively correlated with working memory performance. Diffusion tensor imaging data showed lower fractional anisotropy in patients in the right superior longitudinal fasciculus, the splenium and genu of the corpus callosum, the right uncinate fasciculus and the forceps major, that negatively correlated with subjective memory failures. No differences in blood biomarkers were found. Once patients were classified ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
16 p.; application/pdf |
| Language: |
English |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1093/braincomms/fcaf070; Brain Communications, 2025, vol. 7, num.1; https://doi.org/10.1093/braincomms/fcaf070; https://hdl.handle.net/2445/225339; 756143 |
| Availability: |
https://hdl.handle.net/2445/225339 |
| Rights: |
cc-by (c) Laura Pacheco-Jaime et al., 2025 ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.656E5005 |
| Database: |
BASE |