| Title: |
Immunogenicity and safety of the CoronaVac vaccine in patients undergoing treatment for breast and lung cancer |
| Authors: |
Yakup, İriağaç; Eyyüp, Çavdar; Kubilay, Karaboyun; Okan, Avcı; Özkan, Alan; Halil, Taşkaynatan; Selçuk, Şeber Erdoğan |
| Publisher Information: |
Aepress Sro |
| Publication Year: |
2022 |
| Subject Terms: |
Vaccine; Coronavac; Cancer; Covid-19; Sars-Cov-2; Chemotherapy |
| Description: |
BACKGROUND: Patients with cancer receiving an active systemic therapy are at a high risk for coronavirus disease (COVID-19); however, the antibody response and long-term results of the inactivated whole-virion SARS-CoV-2 (CoronaVac) vaccine in these patients compared to the non-cancer population are unknown. OBJECTIVE: To compare seroconversion for SARS-CoV-2 receptor-binding domain (RBD) specific IgG positivity against two doses of the CoronaVac vaccine in breast and lung cancer patients receiving systemic therapy, to determine the factors affecting seropositivity, and to observe long-term results up to a secondary booster vaccine. RESULTS: The analysis included 201 cancer patients (99 breasts, 102 lungs; median age: 59 years (range: 28-92), 42.3 % men) and 97 controls (median age: 62 years (range: 24-87), 38.1 % men). The seropositivity rate for RBD IgG after 2 doses of vaccine in the cancer group was 81.6 % (n=164) and 93.8 % (n=91) in the control group (p=0.005). The median IgG titer of cancer patients was significantly lower than in the control group (338 (IQR, 95-933) AU/mL vs 676 (IQR, 389-1270) AU/mL; p= 60 patients than in |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Bratislava Medical Journal-Bratislavske Lekarske Listy; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4149/BLL_2022_063; https://hdl.handle.net/20.500.11776/10846; 123; 401; 407; Q4; WOS:000800441700003; Q3 |
| DOI: |
10.4149/BLL_2022_063 |
| Availability: |
https://hdl.handle.net/20.500.11776/10846; https://doi.org/10.4149/BLL_2022_063 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.657DFF73 |
| Database: |
BASE |