| Title: |
The 2024 UK clinical guideline for the prevention and treatment of osteoporosis |
| Authors: |
Gregson, C.L.; Armstrong, D.J.; Avgerinou, C.; Bowden, J.; Cooper, C.; Douglas, L.; Edwards, J.; Gittoes, N.J.L.; Harvey, N.C.; Kanis, J.A.; Leyland, S.; Low, R.; McCloskey, E.; Moss, K.; Parker, J.; Paskins, Z.; Poole, K.; Reid, D.M.; Stone, M.; Tomson, J.; Vine, N.; Compston, J. |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2025 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Summary The National Osteoporosis Guideline Group (NOGG) has updated the revised UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. This guideline is relevant for all healthcare professionals involved in osteoporosis management. Introduction The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013, 2017 and 2021. This paper presents a minor update of the 2021 guideline, the scope of which is to review the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women and men aged 50 years and older. Methods Where available, systematic reviews, meta-analyses and randomised controlled trials have been used to provide the evidence base. Conclusions and recommendations have been systematically graded according to the strength of the available evidence. Results Review of the evidence and recommendations are provided for the diagnosis of osteoporosis, fracture-risk assessment and intervention thresholds, management of vertebral fractures, non-pharmacological and pharmacological treatments, including duration and monitoring of anti-resorptive therapy, glucocorticoid-induced osteoporosis, as well as models of care for fracture prevention. Recommendations are made for training, service leads and commissioners of healthcare, and for review criteria for audit and quality improvement. Specific 2024 updates include guidance on fracture risk assessment by ethnicity, Parkinson’s disease, Down’s syndrome and lower-limb amputation; furthermore, the definition of very high fracture risk has been clarified. Hormone replacement therapy (HRT) is now recommended as a first-line treatment option in younger postmenopausal women with high fracture risk and low baseline risk for adverse events; recommendations regarding abaloparatide are included; additional training resources have been ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1862-3522 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/231628/1/s11657-025-01588-3.pdf; Gregson, C.L., Armstrong, D.J., Avgerinou, C. et al. (19 more authors) (2025) The 2024 UK clinical guideline for the prevention and treatment of osteoporosis. Archives of Osteoporosis, 20 (1). 119. ISSN: 1862-3522 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/231628/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.658A6BF5 |
| Database: |
BASE |