| Title: |
Nasopharyngeal and oral microbiota profiling in SARS-CoV-2 infected pregnant women |
| Authors: |
Giovannini N.; Limena A.; Ercolino C.; Renteria S. C. U.; Strati F.; Giuffre M. R.; Maragno P.; Carbone I. F.; Facciotti F.; Ceriotti F.; Ferrazzi E.; Lattuada D. |
| Contributors: |
Giovannini, N; Limena, A; Ercolino, C; Renteria, S; Strati, F; Giuffre, M; Maragno, P; Carbone, I; Facciotti, F; Ceriotti, F; Ferrazzi, E; Lattuada, D |
| Publisher Information: |
Nature Research; GB |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Nasopharyngeal and oral microbiota; Pregnancy; SARS-CoV-2 |
| Description: |
Variations have been found in the upper respiratory tract microbiota in SARS-CoV-2 positive patients compared to healthy subjects, with different dominant species and diversity indexes detected, including a decrease in biodiversity and an increased abundance of bacterial pathogens. Moreover, these discrepancies were observed in patients with both mild and severe symptoms. Notably, the inflammatory state appears to be significantly influenced by the characteristics of the indigenous microbiota. This is particularly interesting in pregnant patients, as pregnancy involves an adaptive adjustment of the microbiota due to hormonal changes aimed at providing immune protection. The relationship between the microbiota of pregnant women and SARS-CoV-2 has not been deeply explored so far. The purpose of the present study is to investigate the relationship between SARS-CoV-2, nasopharyngeal and oral microbiota, and pregnancy. To our knowledge this is the first simultaneous investigation on both nasopharyngeal and oral microbiota in SARS-Cov-2 infected pregnant women. In this study, the nasopharyngeal and oral microbiota were analysed in 43 women in their third trimester of pregnancy enrolled from April 2020 to February 2021. The differential abundance of taxa was tested and alpha and beta diversity were evaluated. SARS-CoV-2 infected pregnant women showed an alteration of the nasopharyngeal and oral microbiota compared to healthy pregnant women. In both the nasopharyngeal and oral microbiota of the SARS-CoV-2 infected pregnant women, we found a variation in taxa, represented by an enrichment of pathobionts, which increased particularly with the severity of symptoms. Specifically, a significant reduction in microbial biodiversity has been identified within the nasopharyngeal microbiota of SARS-CoV-2 positive women. Furthermore, enrichment in pathobionts was noted in both asymptomatic and symptomatic women, with these changes being more pronounced in the nasopharyngeal microbiota compared to the oral one. The nasopharyngeal ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41068233; info:eu-repo/semantics/altIdentifier/wos/WOS:001591464800040; volume:15; issue:1; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/10281/576206 |
| DOI: |
10.1038/s41598-025-19344-5 |
| Availability: |
https://hdl.handle.net/10281/576206; https://doi.org/10.1038/s41598-025-19344-5 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.65BBF1DB |
| Database: |
BASE |