| Title: |
Profile of mild/moderate asthma patients: Baseline data from the MANI cohort |
| Authors: |
Carpagnano G. E.; Bonini M.; Latorre M.; Nucera E.; Prediletto I.; Puggioni F.; Scioscia G.; Santus P.; Sotgiu G.; Blasi F.; Canonica G. W.; Paggiaro P.; Aruanno A.; Baiardini I.; Bagnasco D.; Bondi B.; Candeliere G.; Cefaloni F.; Fontanili G.; Melissari L.; Mincarini M.; Paoletti G.; Radovanovic D.; Pinelli V.; Tondo P.; Quaranta V. N.; Vallara R.; Braido F. |
| Contributors: |
Carpagnano, G. E.; Bonini, M.; Latorre, M.; Nucera, E.; Prediletto, I.; Puggioni, F.; Scioscia, G.; Santus, P.; Sotgiu, G.; Blasi, F.; Canonica, G. W.; Paggiaro, P.; Aruanno, A.; Baiardini, I.; Bagnasco, D.; Bondi, B.; Candeliere, G.; Cefaloni, F.; Fontanili, G.; Melissari, L.; Mincarini, M.; Paoletti, G.; Radovanovic, D.; Pinelli, V.; Tondo, P.; Quaranta, V. N.; Vallara, R.; Braido, F. |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Asthma; Control; Mild; Moderate; Rea life |
| Description: |
Although 90% of asthmatic patients suffer from mild and moderate disease, little is known about the burden on health status and quality of life, the long-term trajectory of disease severity, and the socio-economic impact. The Mild Moderated Asthma Network of Italy (MANI) is a real-world, crosssectional, prospective, observational cohort study designed to explore these issues. Here we aimed to provide an identikit of asthmatic patients receiving treatment according to GINA steps 1-4, and enrolled in the centers of excellence participating in the MANI. Among 679 analyzed patients, 63% were female, and the mean age was 50 +/- 16 years. Asthma was mild in 15.8% of patients (GINA steps 1-2) and moderate in 84.2% (GINA steps 3-4). The mean age of asthma diagnosis was 34.3 +/- 17.7 years, 50% of patients were suffering from allergic rhinitis, and 13% from nasal polyposis. Mean FEV1% was 91.4 +/- 19.4%, predicted with a FEV1/FVC ratio of 74.7 +/- 11.9. The mean asthma control test value was 21.2 +/- 3.73, and AQLQ score was 5.74 +/- 1.07. Among the included patients, 17.2% had at least one asthma exacerbation in the previous year, with 14.2% requiring systemic steroids; 6.2% were referred to an emergency room in the year prior to enrollment; 2.2% required an asthma-related hospitalization; and 0.6% had been admitted to an Intensive Care Unit (ICU). Unscheduled visits were necessary for 3.8% of patients, 6.5% reported >5 lost work days due to asthma, and 11.5% declared >10 lost days of spare time. About 70% of patients were receiving treatment according to GINA Track 1. Uncontrolled cases constituted 16.7% of patients treated according to GINA steps 1-2, and 26.3% of patients treated according to GINA steps 3-4 were uncontrolled. Compared to patients with mild asthma, those with moderate asthma had more impaired lung function (FEV1% 88.5 +/- 18.4 vs 94.4 +/- 17.9, p = 0.05; FEV1/FVC 73.0 +/- 9.76 vs 79.6 +/- 9.56, p > 0.001), exhibited greater need for systemic corticosteroids for treating exacerbations (13.8% ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40689384; info:eu-repo/semantics/altIdentifier/wos/WOS:001528689000001; volume:18; issue:8; firstpage:1; lastpage:13; numberofpages:13; journal:THE WORLD ALLERGY ORGANIZATION JOURNAL; https://hdl.handle.net/11585/1045130; https://www.sciencedirect.com/science/article/pii/S1939455125000596?via=ihub |
| DOI: |
10.1016/j.waojou.2025.101082 |
| Availability: |
https://hdl.handle.net/11585/1045130; https://doi.org/10.1016/j.waojou.2025.101082; https://www.sciencedirect.com/science/article/pii/S1939455125000596?via=ihub |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND) ; license uri:iris.PUB17 |
| Accession Number: |
edsbas.65C053FC |
| Database: |
BASE |