| Title: |
Interpreting generative adversarial networks to infer natural selection from genetic data |
| Authors: |
Riley, Rebecca; Mathieson, Iain; Mathieson, Sara |
| Contributors: |
Ralph, P |
| Source: |
GENETICS ; volume 226, issue 4 ; ISSN 1943-2631 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Understanding natural selection and other forms of non-neutrality is a major focus for the use of machine learning in population genetics. Existing methods rely on computationally intensive simulated training data. Unlike efficient neutral coalescent simulations for demographic inference, realistic simulations of selection typically require slow forward simulations. Because there are many possible modes of selection, a high dimensional parameter space must be explored, with no guarantee that the simulated models are close to the real processes. Finally, it is difficult to interpret trained neural networks, leading to a lack of understanding about what features contribute to classification. Here we develop a new approach to detect selection and other local evolutionary processes that requires relatively few selection simulations during training. We build upon a generative adversarial network trained to simulate realistic neutral data. This consists of a generator (fitted demographic model), and a discriminator (convolutional neural network) that predicts whether a genomic region is real or fake. As the generator can only generate data under neutral demographic processes, regions of real data that the discriminator recognizes as having a high probability of being “real” do not fit the neutral demographic model and are therefore candidates for targets of selection. To incentivize identification of a specific mode of selection, we fine-tune the discriminator with a small number of custom non-neutral simulations. We show that this approach has high power to detect various forms of selection in simulations, and that it finds regions under positive selection identified by state-of-the-art population genetic methods in three human populations. Finally, we show how to interpret the trained networks by clustering hidden units of the discriminator based on their correlation patterns with known summary statistics. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/genetics/iyae024 |
| DOI: |
10.1093/genetics/iyae024/56875636/iyae024.pdf |
| Availability: |
https://doi.org/10.1093/genetics/iyae024; https://academic.oup.com/genetics/advance-article-pdf/doi/10.1093/genetics/iyae024/56875636/iyae024.pdf; https://academic.oup.com/genetics/article-pdf/226/4/iyae024/59153583/iyae024.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.65C26A40 |
| Database: |
BASE |