Revascularisation or medical therapy in elderly patients with acute anginal syndromes (RINCAL) a randomised trial
| Title: | Revascularisation or medical therapy in elderly patients with acute anginal syndromes (RINCAL) a randomised trial |
|---|---|
| Authors: | de Belder, Adam; Myat, Aung; Blaxill, Jonathan; Haworth, Peter; O’Kane, Peter; Hatrick, Robert; Aggarwal, Rajesh; Davie, Andrew; Smith, William; Gerber, Robert; Byrne, Jonathan; Adamson, Dawn; Witherow, Fraser; Alsanjari, Osama; Wright, Juliet; Robinson, Derek R; Hildick-Smith, David |
| Publisher Information: | Europa Group |
| Publication Year: | 2021 |
| Collection: | University of Sussex: Sussex Research Online |
| Description: | Aims: To determine whether an intervention-guided strategy is superior to optimal medical therapy (OMT) for treating non-ST-elevation myocardial infarction (NSTEMI) in the elderly. Methods and results: Patients (≥80 years, chest pain, ischaemic ECG, and elevated troponin) were randomised 1:1 to an invasive strategy plus OMT versus OMT alone. The combined primary endpoint was all-cause mortality and non-fatal myocardial re-infarction at 1 year. We enrolled 251 patients (n=125 invasive vs. n=126 conservative) from May 2014 to September 2018. Almost half were female. The trial was terminated prematurely due to slow recruitment. A Kaplan-Meier estimate of event-free survival revealed no difference in the primary combined endpoint (invasive 18.5% [23/124] vs. conservative 22.2% [28/126]; p=0.39) or in all-cause mortality alone (invasive 10.5% [13/124] vs. conservative 11.1% [14/126]; p=0.88). There was less angina at 3 months (p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1969-6213 |
| Relation: | http://sro.sussex.ac.uk/id/eprint/95922/3/RINCAL.pdf; de Belder, Adam, Myat, Aung, Blaxill, Jonathan, Haworth, Peter, O’Kane, Peter, Hatrick, Robert, Aggarwal, Rajesh, Davie, Andrew, Smith, William, Gerber, Robert, Byrne, Jonathan, Adamson, Dawn, Witherow, Fraser, Alsanjari, Osama, Wright, Juliet, Robinson, Derek R and Hildick-Smith, David (2021) Revascularisation or medical therapy in elderly patients with acute anginal syndromes (RINCAL) a randomised trial. EuroIntervention, 17 (1). pp. 67-74. ISSN 1969-6213 |
| DOI: | 10.4244/eij-d-20-00975 |
| Availability: | http://sro.sussex.ac.uk/id/eprint/95922/; http://sro.sussex.ac.uk/id/eprint/95922/3/RINCAL.pdf; https://doi.org/10.4244/eij-d-20-00975 |
| Accession Number: | edsbas.65E57B12 |
| Database: | BASE |