Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEA tC
| Title: | Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEA tC |
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| Authors: | Shalamberidze, Ana; Pearce, Harrison R.; Cooksy, Andrew L.; Purse, Byron W. |
| Contributors: | National Science Foundation |
| Source: | RSC Chemical Biology ; volume 7, issue 2, page 216-225 ; ISSN 2633-0679 |
| Publisher Information: | Royal Society of Chemistry (RSC) |
| Publication Year: | 2026 |
| Description: | In solution and single-stranded DNA, DEA tC predominantly adopts a weakly emissive thymine-like tautomer, whereas base pairing with guanine or inosine stabilizes its bright cytidine-like tautomer, yielding a sequence-dependent fluorescence increase. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1039/d5cb00243e |
| Availability: | https://doi.org/10.1039/d5cb00243e; http://pubs.rsc.org/en/content/articlepdf/2026/CB/D5CB00243E |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Accession Number: | edsbas.6627B2BC |
| Database: | BASE |