| Title: |
Effects of sugar-sweetened beverage consumption on microvascular and macrovascular function in a healthy population |
| Authors: |
Loader, J.; Meziat, C.; Watts, R.; Lorenzen, C.; Sigaudo-Roussel, D.; Stewart, S.; Reboul, C.; Meyer, G.; Walther, G. |
| Source: |
http://dx.doi.org/10.1161/atvbaha.116.308010. |
| Publisher Information: |
American Heart Association, Inc. |
| Publication Year: |
2017 |
| Collection: |
The University of Adelaide: Digital Library |
| Subject Terms: |
Acetylcholine; antioxidants; brachial artery; endothelium; hyperglycemia |
| Description: |
Objective: To assess vascular function during acute hyperglycemia induced by commercial sugar-sweetened beverage (SSB) consumption and its effect on underlying mechanisms of the nitric oxide pathway. Approach and Results: In a randomized, single-blind, crossover trial, 12 healthy male participants consumed 600 mL (20 oz.) of water or a commercial SSB across 2 visits. Endothelial and vascular smooth muscle functions were assessed in the microcirculation using laser speckle contrast imaging coupled with iontophoresis and in the macrocirculation using brachial artery ultrasound with flow- and nitrate-mediated dilation. Compared with water, SSB consumption impaired microvascular and macrovascular endothelial function as indicated by a decrease in the vascular response to acetylcholine iontophoresis (208.3±24.3 versus 144.2±15.7%, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1079-5642; 1524-4636 |
| Relation: |
NHMRC; Arteriosclerosis, Thrombosis and Vascular Biology, 2017; 37(6):1250-1260; http://hdl.handle.net/2440/111813; Stewart, S. [0000-0001-9032-8998] |
| DOI: |
10.1161/ATVBAHA.116.308010 |
| Availability: |
http://hdl.handle.net/2440/111813; https://doi.org/10.1161/ATVBAHA.116.308010 |
| Rights: |
© 2017 American Heart Association, Inc. |
| Accession Number: |
edsbas.669469F6 |
| Database: |
BASE |