| Title: |
Acute myeloid leukemia with RAM immunophenotype: A new underdiagnosed entity |
| Authors: |
Gajendra, Smeeta; Anupurba, Shilpa; Gupta, Ritu; Mallick, Saumyaranjan; Panda, Devasis; Thakral, Deepshi; Gupta, Sanjeev Kumar; Bakhshi, Sameer; Seth, Rachna; Rai, Sandeep; Prajapati, Vijay K.; Singh, Saroj |
| Contributors: |
Indian Council of Medical Research |
| Source: |
International Journal of Laboratory Hematology ; volume 45, issue 4, page 541-552 ; ISSN 1751-5521 1751-553X |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Introduction Acute myeloid leukemia (AML) with RAM immunophenotype is a distinct subtype of AML, as described by the Children's Oncology Group (COG), with characteristic morphological and immunophenotypic properties. It is characterized by strong CD56 expression with dim to negative CD45, HLA‐DR, and CD38 expression. It is an aggressive leukemia with a poor response to induction chemotherapy and/or frequent relapses. Methods Seven cases with the characteristic RAM immunophenotype were identified in this retrospective analysis of newly diagnosed pediatric AML cases from January 2019 to December 2021. Herein, we have critically analyzed their clinical, morphological, cytochemical, immunophenotyping, cytogenetic, and molecular profiles. The patients were traced and followed for their current disease and treatment status. Results Of 302 cases of pediatric AML (age |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/ijlh.14076 |
| Availability: |
https://doi.org/10.1111/ijlh.14076; https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijlh.14076 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.66EECC1 |
| Database: |
BASE |