| Title: |
Skull-Base Chondrosarcoma: A Systematic Review of the Role of Postoperative Radiotherapy |
| Authors: |
Pawan Kishore Ravindran; Max E. Keizer; Henricus (Dirk) P. M. Kunst; Inge Compter; Jasper Van Aalst; Daniëlle B. P. Eekers; Yasin Temel |
| Source: |
Cancers, Vol 16, Iss 5, p 856 (2024) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2024 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
skull base; chondrosarcoma; low grade; radiotherapy; surgery; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Surgery and radiotherapy are key elements to the treatment of skull-base chondrosarcomas; however, there is currently no consensus regarding whether or not adjuvant radiotherapy has to be administered. This study searched the EMBASE, Cochrane, and PubMed databases for clinical studies evaluating the long-term prognosis of surgery with or without adjuvant radiotherapy. After reviewing the search results, a total of 22 articles were selected for this review. A total of 1388 patients were included in this cohort, of which 186 received surgery only. With mean follow-up periods ranging from 39.1 to 86 months, surgical treatment provided progression-free survival (PFS) rates ranging from 83.7 to 92.9% at 3 years, 60.0 to 92.9% at 5 years, and 58.2 to 64.0% at 10 years. Postoperative radiotherapy provides PFS rates ranging between 87 and 96.2% at 3 years, 57.1 and 100% at 5 years, and 67 and 100% at 10 years. Recurrence rates varied from 5.3% to 39.0% in the surgery-only approach and between 1.5% and 42.90% for the postoperative radiotherapy group. When considering prognostic variables, higher age, brainstem/optic apparatus compression, and larger tumor volume prior to radiotherapy were found to be significant factors for local recurrence. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2072-6694/16/5/856; https://doaj.org/toc/2072-6694; https://doaj.org/article/be464365a12b428e8193f4d7362ad87e |
| DOI: |
10.3390/cancers16050856 |
| Availability: |
https://doi.org/10.3390/cancers16050856; https://doaj.org/article/be464365a12b428e8193f4d7362ad87e |
| Accession Number: |
edsbas.66F347F5 |
| Database: |
BASE |